One of the clinical features of cystic fibrosis (CF) is a deep inflammatory process, which is characterized by production and release of cytokines and chemokines, among which interleukin 8 (IL-8) represents one of the most important. Accordingly, there is a growing interest in developing therapies against CF to reduce the excessive inflammatory response in the airways of CF patients. Since tran...

There is no documentation in the literature of the risk of hypoxemia after chest percussion in acutely ill adults with nonsurgical pulmonary disorders. We studied the immediate effect of postural drainage and chest percussion (PDP) on oxygenation in 22 hospitalized patients with a variety of acute, nonsurgical pulmonary disorders. Heart rate, respiratory rate, blood pressure, and arterial blood...

Motivations of CMOS technology scaling are higher speed of operation, benefit of integration density and lower power dissipation. CMOS technology has crossed many hurdles over the past four decades. The aggressive technology scaling is causing device parameter variations, which is more severe than earlier. This paper carries out variability analysis of various popular exclusive-OR circuits at t...

OBJECTIVES To describe the development, implementation, and preliminary outcome of the Pain-Disability Prevention (PDP) Program. The PDP Program is a 10-week cognitive-behavioral intervention program that aims to increase daily involvement in goal-directed activity and minimize psychological barriers to activity involvement after occupational injury. Workers' Compensation Board claimants with s...

This paper defines a multiobjective variant of the Pickup and Delivery Problem (PDP), called PDP with Time Windows and Demands (PDP-TW-D), and approaches the problem with a novel memetic optimization algorithm. With respect to multiple optimization objectives, the goal of PDP-TW-D is to find a set of Pareto-optimal routes for a fleet of vehicles in order to serve given transportation requests. ...

Spend your few moment to read a book even only few pages. Reading book is not obligation and force for everybody. When you don't want to read, you can get punishment from the publisher. Read a book becomes a choice of your different characteristics. Many people with reading habit will always be enjoyable to read, or on the contrary. For some reasons, this assembly language programming for pdp 1...

Vascular injury after balloon angioplasty results in the rapid activation of platelets leading to the release of growth factors and vasoactive substances. In addition, up-regulation of tissue factor (TF) and an increased production of reactive oxygen species (ROS) have been detected at sites of vascular injury. We investigated whether platelet-derived products (PDP) released from activated huma...

This paper introduces a special issue of Cognitive Science initiated on the 25th anniversary of the publication of Parallel Distributed Processing (PDP), a two-volume work that introduced the use of neural network models as vehicles for understanding cognition. The collection surveys the core commitments of the PDP framework, the key issues the framework has addressed, and the debates the frame...

Network virtualization provides the ability to run multiple concurrent virtual networks over a shared substrate. However, it is challenging to design such a platform to host multiple heterogenous and often highly customized virtual networks. Not only high degree of flexibility is desired for virtual networks to customize their functions, fast packet forwarding is also required. This paper prese...

The insulin/IGF-1 signaling (IIS) pathway is a conserved regulator of longevity, development, and metabolism. In Caenorhabditis elegans IIS involves activation of DAF-2 (insulin/IGF-1 receptor tyrosine kinase), AGE-1 (PI 3-kinase), and additional downstream serine/threonine kinases that ultimately phosphorylate and negatively regulate the single FOXO transcription factor homolog DAF-16. Phospha...