Abstract Background T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease with a high risk of induction failure and poor outcomes, relapse due to drug resistance. Recent studies show that bromodomains extra-terminal (BET) protein inhibitors are promising anti-cancer agents. ARV-825, comprising BET inhibitor conjugated cereblon ligand, was recently developed attenuate the growth m...

Addition of sucrose (413-825 mmol/L) to human serum allows plasma lipoproteins to be lyophilized without denaturation. A control serum so prepared is especially suited for use in monitoring determinations of apolipoproteins and quantitative lipoprotein electrophoresis. It is clear upon reconstitution; hence, the described procedure may also be useful for preparation of control sera for general ...

Sheldon K. Friedlander and David Y. H. Pui Department of Chemical Engineering, 5531-K Boelter Hall, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA 90095, USA (Tel: 310-825-2206; Fax: 310-206-4107; E-mail: [email protected]); Director of the Particle Technology Laboratory, Mechanical Engineering Department, University of Minnesota, 111 Church St., S.E., Minneapolis, M...

Commutator structure of operator ideals Ken Dykema, ,1 Tadeusz Figiel, Gary Weiss, and Mariusz Wodzicki Department of Mathematics, Texas A&M University, College Station, TX 77843-3368, USA b Instytut Matematyczny Polskiej Akademii Nauk, 81-825 Sopot, Poland Department of Mathematical Sciences, University of Cincinnati, Cincinnati, OH 45221-0025, USA Department of Mathematics, University of Cali...

President Obama has proposed an overall budget increase of $825 million for the NIH in fiscal year 2017 compared with 2016. That money would be reserved for three efforts: the NCI's "moonshot" initiative, the Precision Medicine Initiative cohort program, and the BRAIN program.

Center for Inflammatory Bowel Diseases; Division of Digestive Diseases, David Geffen School of Medicine, The University of California Los Angeles, Los Angeles, CA Corresponding author: Hon Wai Koon, Ph.D. Center for Inflammatory Bowel Diseases, MRL 1519, 675 Charles E. Young Drive South, The University of California Los Angeles, Los Angeles, CA 90095, U.S.A. Tel: 310-825-9742 Email: hkoon@medne...