The cyclin-dependent kinase inhibitor p21 has been characterized as an important effector of the tumor suppressor p53 and has been linked to various growth-regulatory processes. To identify a potential role of p21 in anchorage-dependent growth control, we analyzed a pair of HCT116 human colon carcinoma cell lines that differed only in their p21 status. We found that during suspension culture, H...

Abstract Mesoporous carbon spheres (MCSs) are widely used in the field of pollutants adsorption, energy storage and various biomedicine applications such as targeted delivery vector, phototherapy sensitizers, bioimaging contrast agents, etc. Current synthetic strategies including soft templating hard methods generally have limits using expensive surfactants or lack control over pore structures....

One ultimate goal of metabolic network modeling is the rational redesign of biochemical networks to optimize the production of certain compounds by cellular systems. Although several constraint-based optimization techniques have been developed for this purpose, methods for systematic enumeration of intervention strategies in genome-scale metabolic networks are still lacking. In principle, Minim...

Mixed-Criticality Systems (MCSs) include tasks with multiple levels of criticality and different modes operation. These systems bring benefits such as energy resource saving while ensuring safe However, management available resources in order to achieve high utilization, low power consumption, required reliability level is challenging MCSs. In many cases, there a trade-off between these goals. ...

The scientific literature is voluminous with respect to the cloud-to-ground (CG) lightning and electrical characteristics of mesoscale convective systems (MCSs). MacGorman and Morgenstern (1998) define an MCS as a long-lived storm system that amalgamates from a group of smaller storms through interactions with the local environment. One of the more common types of MCS is the squall line, which ...

It is becoming recognized that screening of oncology drugs on a platform using two-dimensionally (2D)-cultured cell lines is unable to precisely select clinically active drugs; therefore three-dimensional (3D)-culture systems are emerging and show potential for better simulating the in vivo tumor microenvironment. The purpose of this study was to reveal the differential effects of chemotherapeu...

The climatology of convection over northern Australia and the surrounding oceans, based on six wet seasons (September–April), is derived from the Japanese Meteorological Agency Geostationary Meteorological Satellite-5 (GMS-5) IR1 channel for the years from 1995/96 to 2000/01. This is the first multiyear study of this kind. Clouds are identified at two cloud-top temperature thresholds: 235 and 2...

A minimal cut set is a minimal set of reactions whose inactivation would guarantee a failure in a certain network function or functions. Minimal cut sets (MCSs) were initially developed from the metabolic pathway analysis method (MPA) of elementary modes (EMs); they provide a way of identifying target genes for eliminating a certain objective function from a holistic perspective that takes into...

[1] Previous observational studies have identified three different types of diurnal precipitation variation over the conterminous U.S.: localized afternoon rainfall maxima over the Mississippi and Ohio valleys, propagating mesoscale convective systems (MCSs) from the Rocky Mountain region, and propagating MCSs over the Appalachian Mountains. This study focuses on the second type, which involves...

Ovarian cancer is the deadliest of all gynecologic malignancies. Metastatic ovarian cancer cells exist mainly in the form of multi-cellular spheroids (MCSs) in the ascites of patients with advanced ovarian cancer. We hypothesized that E-cadherin, as an important cell-adhesion molecule, might play an important role in the formation and survival of MCSs. Therefore, we established a three-dimensio...