Acute hyperglycemia (AHG) decreases the availability of nitric oxide (NO) and impairs anesthetic preconditioning (APC)-elicited protection against myocardial infarction. We investigated whether D-4F, an apolipoprotein A-1 mimetic, rescues the myocardium by promoting APC-induced endothelial NO signaling during AHG. Myocardial infarct size was measured in mice in the absence or presence of APC [i...

Our previous results demonstrated that the apolipoprotein A-I (apoA-I) mimetic peptides L-4F and L-5F inhibit vascular endothelial growth factor production and tumor angiogenesis. The present study was designed to test whether apoA-I mimetic peptides inhibit the expression and activity of hypoxia-inducible factor-1α (HIF-1α), which plays a critical role in the production of angiogenic factors a...

OBJECTIVE To determine the effect of the apolipoprotein A-I (ApoA-I) mimetic peptide, D-4F, on atherosclerosis development in a pre-existing diabetic condition. RESEARCH DESIGN AND METHODS We induced hyperglycemia in 6-week-old apoE(-/-) female mice using streptozotocin. Half of the diabetic apoE(-/-) mice received D-4F in drinking water. Ten weeks later, plasma lipids, glucose, insulin level...

An apolipoprotein A-I mimetic peptide, D-4F, has been shown to improve vasodilation and inhibit atherosclerosis in hypercholesterolemic low-density lipoprotein receptor-null (LDLr(-/-)) mice. To study the metabolic variations of D-4F ininhibiting atherosclerosis, metabonomics, a novel system biological strategy to investigate the pathogenesis, was developed. Female LDLr(-/-) mice were fed a Wes...

High-resolution resonance-photoemission spectroscopy has been performed on the Ce1-xLaxRhAs (0≤x≤0.05) single crystal to elucidate a collapse of the energy gap in the Kondo semiconductor CeRhAs by La substitution. With increasing x, the spectral intensity of the Ce 4f derived states near the Fermi level decreases and new 4f derived spectral feature appears at a higher binding energy. The Rh 4d-...

Of the 52 known elemental superconductors among the 92 naturally occurring elements in the periodic table, fully 22 only become superconducting under sufficiently high pressure. In the rare-earth metals, the strong local magnetic moments originating from the 4f shell suppress superconductivity. For Eu, however, Johansson and Rosengren have suggested that sufficiently high pressures should promo...

An accurate knowledge of the Li i 4d–4f energy separation is essential for the determination of electric fields, as is pursued using several modern diagnostic techniques. However, there is a rather large spread in the values of this quantity in the available data sources. We have measured the Li i 4d–4f energy separation using a technique that combines laser-induced-fluorescence with the utiliz...

OBJECTIVE The apolipoprotein A-I (apoA-I) mimetic peptide 4F favors the differentiation of human monocytes to an anti-inflammatory phenotype and attenuates lipopolysaccharide (LPS)-induced inflammatory responses. We investigated the effects of LPS on the Toll-like receptor (TLR) signaling pathway in 4F-differentiated monocyte-derived macrophages. METHODS AND RESULTS Monocyte-derived macrophag...

Three octanuclear phosphonate clusters, formulated as [Ln8(O3P(t)Bu)6(μ3-OH)2(H2O)2(HO(i)Bu)(O2C(t)Bu)12](NH3(i)Pr)2 (Ln = Gd, Dy and Tb), were synthesised by refluxing a mixture of pivalic acid (HO2C(t)Bu), Ln(NO3)3·6H2O, tert-Butyl phosphonic acid (H2O3P(t)Bu) and isopropylamine ((i)PrNH2) in isobutyl alcohol (i)BuOH.