TEF and RTEF-1 Binding to the Smooth Muscle -Actin Gene Distinguishes Myofibroblasts and Adult Smooth Muscle Cells Adult smooth muscle cells are highly plastic and can exhibit a range of phenotypes in response to different environmental and developmental cues. Their phenotypes can range from quiescent highly contractile cells with high levels of characteristic contractile protein isoforms, to h...

So, you want to write a letter to the editor? A recent editorial by Golub in JAMA prompted us to outline more fully our vision of Annals of Emergency Medicine’s Correspondence section and its place within the journal and the peer review process. Like most peer-reviewed publications, Annals of Emergency Medicine contains a correspondence section, commonly known as Letters to the Editor. Journals...

Language is a brilliant invention of the mind. Normal language acquisition in humans is characterized by spectacularly quick, effortless, uninstructed learning, and leads to universal linguistic competence. Remarkably, no other species has evolved as sophisticated a system of combinatorial symbolic communication. Just as echolocation allows bats and dolphins to orient themselves and locate othe...

A semi-synthetic organism with an extended genetic alphabet heralds a new era in synthetic biology.