To elucidate the significance of tRNA modification for human lymphoid maturation and malignant transformation, the amount of tRNAs having guanosine in place of queuosine, i.e., (Q-)tRNA, was determined in several human lymphomas and leukemias by exchanging the respective unmodified guanosine residue for [3H]guanine, a reaction catalyzed by a specific tRNA transglycosylase from Escherichia coli....

To elucidate the significance of tRNA modification for human lymphoid maturation and malignant transformation, the amount of tRNAs having guanosine in place of queuosine, i.e., (Q-)tRNA, was determined in several human lymphomas and leukemias by exchanging the respective unmodified guanosine residue for [3H]guanine, a reaction catalyzed by a specific tRNA transglycosylase from Escherichia coli....

Cholecystokinin (CCK) is a growth factor for normal pancreas. Nu merous studies also suggest that CCK promotes pancreatic carcinogenesis in the rat. Our previous studies suggested that growth of preneoplastic pancreatic foci was stimulated by CCK more than that of normal pan creas. We hypothesized that such differential growth might be due to increased numbers of CCK receptors in neoplastic tis...

semantics: k-CFA ((f e), β̂, σ̂, â) ; (e′, β̂′, σ̂′, â′), where Ê(f, β̂, σ̂) ∋ 〈(λ (x) e′), β̂′′〉 â′ = ⌊l · â⌋k Ê(e, β̂, σ̂) = d̂ β̂′ = β̂′′[x 7→ â′] σ̂′ = σ̂ ⊔ [â′ 7→ d̂] And: Ê(x, β̂, σ̂) = σ̂(β̂(x)) Ê((λ (x) e), β̂, σ̂) = {〈(λ (x) e), β̂〉} Resolving and Exploiting the k-CFA Paradox, New England Programming Language and Systems Sysmposium, MIT, December, 2009 – p.5/22 The Paradox of k-CFA Resolving and Exploiting ...

Small-cell carcinoma of the lung is a highly lethal form of cancer associated with a wide variety of paraneoplastic syndromes. Using the patch-clamp technique, we have directly demonstrated the presence of voltage-gated k4. Na4, and (a24 channels in three cell lines of human small-cell carcinoma, NCI-HI28, NCI-H69, and NCI-HI46. Whole-cell currents were measured from the tumor cells held at —...

Small-cell carcinoma of the lung is a highly lethal form of cancer associated with a wide variety of paraneoplastic syndromes. Using the patch-clamp technique, we have directly demonstrated the presence of voltage-gated k4. Na4, and (a24 channels in three cell lines of human small-cell carcinoma, NCI-HI28, NCI-H69, and NCI-HI46. Whole-cell currents were measured from the tumor cells held at —...

Ú ̆ ‰ ‡ Ï , È Â ‡ · was an active, if not the most active, character throughout „ Â „ ’s reign. However, the character of È Â ‡ · and his brothers is foggy and puzzling. Although many of us have been taught to classify figures in Tanach into the roles of either ¢ ˆ „ È ̃ ¢ or ¢ ̄ ̆ Ú ¢ to further our understanding of the manifest context © Ù ̆ Ë ® and latent meaning © „ ̄ ̆ ® of the text, È Â ‡ · and ...

Mechanisms for resistance were studied in three classic type, human small cell lung cancer cell lines, (.!(,,, (.I.(',„,and <;i.<',.i, that were established from one patient during clinical follow-up. Clinically the tumor changed from sensitive (<;!,(,,) to completely resistant to (chemo)therapy ((il.(.',,,) during this period. The stain with JSB-1 anti body, detecting the M, 170,000 multidru...

The electrical potential difference (P.D.) across the cell membrane was measured in monolayers of HeLa cells. At 37°C in the cells' growth medium, the mean P.D. was found to be —1 5.45 ±0.57 my, the cell interior being negative. In Tris buffer the P.D. was —17.10 ±0.71 my. The PD. was tempera ture sensitive, falling to —11.9 my at 27°Cand —9.12my at 17°C.Increasing extracellular K ...