Richard B. Kreider, PhD, MX, EPC, FACSM, FASEP; Anthony L. Almada, MSc; Jose Antonio, PhD, FACSM; Craig Broeder, PhD, FNAASO; Conrad Earnest, PhD, FACSM; Lori Greenwood, PhD, ATC, LAT; Mike Greenwood, PhD, CSCS*D; Thomas Incledon, MS, RD, LD/LN, NSCA-CPT, CSCS, RPT; Douglas S. Kalman MS, RD, FACN; Chad Kerksick, MS, CSCS, ATC, EPC; Susan M. Kleiner, PhD, RD, FACN; Brian Leutholtz, PhD, FACSM; L...

BACKGROUND Endothelial Progenitor Cells (EPC) support neovascularization and regeneration of injured endothelium both by providing a proliferative cell pool capable of differentiation into mature vascular endothelial cells and by secretion of angiogenic growth factors. OBJECTIVE The aim of this study was to investigate the role of PDGF-BB and PDGFRβ in EPC-mediated angiogenesis of differentia...

This paper presents the Lexicon-Grammar classification of Italian idioms that has been constructed on formal principles and, as such, can be exploited in information extraction. Among MWEs, idioms are those fixed constructions which are hard to automatically detect, given their syntactic flexibility and lexical variation. The syntactic properties of idioms have been formally represented and cod...

BACKGROUND Guanylate binding protein-1 (GBP-1) is a large GTPase which is actively secreted by endothelial cells. It is a marker and intracellular inhibitor of endothelial cell proliferation, migration, and invasion. We previously demonstrated that stable expression of GBP-1 in murine endothelial progenitor cells (EPC) induces their premature differentiation and decreases their migration capaci...

Our previous study showed that circulating microvesicles (cMVs) of diabetic mice have negative effects on the function of endothelial progenitor cells (EPCs). Whether this is true in diabetic patients deserves further study. In this study, the effects of cMVs and EPC-derived MVs (EPC-MVs) on EPC migration, apoptosis, and reactive oxygen species (ROS) production in healthy controls, well-control...

Transplantation of bone marrow cells as well as circulating endothelial progenitor cells (EPC) enhances neovascularization after ischemia. The chemokine receptor CXCR4 is essential for migration and homing of hematopoietic stem cells. Therefore, we investigated the role of CXCR4 and its downstream signaling cascade for the angiogenic capacity of cultured human EPC. Ex vivo, differentiated EPC d...

BACKGROUND Bone marrow-derived progenitors for both epithelial and endothelial cells have been observed in the lung. Besides mature endothelial cells (EC) that compose the adult vasculature, endothelial progenitor cells (EPC) are supposed to be released from the bone marrow into the peripheral blood after stimulation by distinct inflammatory injuries. Homing of ex vivo generated bone marrow-der...

BACKGROUND Current evidence suggests that endothelial progenitor cells (EPC) contribute to ischemic tissue repair by both secretion of paracrine factors and incorporation into developing vessels. We tested the hypothesis that cell-free administration of paracrine factors secreted by cultured EPC may achieve an angiogenic effect equivalent to cell therapy. METHODOLOGY/PRINCIPAL FINDINGS EPC-de...

UNLABELLED Aims/Introduction:  Endothelial progenitor cells (EPC) play a critical role in adult vasculogenesis and vascular repair. Previous studies have described the dysfunction of EPC in diabetic patients, but the precise mechanism is still unclear. To elucidate the dysfunction of EPC in diabetic patients, we investigated the functions and intracellular signaling of EPC under normal or high ...