نتایج جستجو برای: اثر plc

تعداد نتایج: 154670  

Journal: :The Biochemical journal 2009
Sandesh Subramanya C Frank Hardin Dietmar Steverding Kojo Mensa-Wilmot

GPI-PLC (glycosylphosphatidylinositol-specific phospholipase C) is expressed in bloodstream-form Trypanosoma brucei, a protozoan that causes human African trypanosomiasis. Loss of genes encoding GPI-PLC reduces the virulence of a pleomorphic strain of the parasite, for reasons that are not clear. In the present paper, we report that GPI-PLC stimulates endocytosis of transferrin by 300-500%. Sur...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2010
Xiao Ping He Enhui Pan Carla Sciarretta Liliana Minichiello James O McNamara

The BDNF receptor, TrkB, is critical to limbic epileptogenesis, but the responsible downstream signaling pathways are unknown. We hypothesized that TrkB-dependent activation of phospholipase Cgamma1 (PLCgamma1) signaling is the key pathway and tested this in trkB(PLC/PLC) mice carrying a mutation (Y816F) that uncouples TrkB from PLCgamma1. Biochemical measures revealed activation of both TrkB a...

Journal: :Journal of bacteriology 1987
R M Ostroff M L Vasil

The phospholipase C (PLC) gene of Pseudomonas aeruginosa encodes a heat-labile secreted hemolysin which is part of a Pi-regulated operon. The structural gene for PLC, plcS, was mutated in vitro by insertion of a tetracycline resistance gene cartridge. Gene replacement techniques were used to introduce the mutated plcS gene into the P. aeruginosa chromosome in place of the wild-type gene. The pr...

Journal: :The Journal of biological chemistry 2006
Elliott M Ross Dania Mateu Aldrin V Gomes Carlos Arana Thanh Tran Irene Litosch

Signaling from G protein-coupled receptors to phospholipase C-beta (PLC-beta) is regulated by coordinate interactions among multiple intracellular signaling molecules. Phosphatidic acid (PA), a signaling phospholipid, binds to and stimulates PLC-beta(1) through a mechanism that requires the PLC-beta(1) C-terminal domain. PA also modulates Galpha(q) stimulation of PLC-beta(1). These data suggest...

Journal: :American journal of physiology. Heart and circulatory physiology 2008
Christopher J Clarke Simon Forman James Pritchett Vasken Ohanian Jacqueline Ohanian

Vasoconstrictors activate phospholipase C (PLC), which hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP(2)), leading to calcium mobilization, protein kinase C activation, and contraction. Our aim was to investigate whether PLC-delta(1), a PLC isoform implicated in alpha(1)-adrenoreceptor signaling and the pathogenesis of hypertension, is involved in noradrenaline (NA) or endothelin (ET-1)-...

Journal: :Advances in educational technology and psychology 2023

Based on the research ideological and political education in course "Machine Tool Electrical PLC", this article explores how to integrate into machine tool electrical PLC course. By analyzing characteristics of PLC" advantages integrating it education, corresponding improvement measures are proposed provide useful reference for higher teaching practice.

Journal: :The Journal of Experimental Medicine 1991
A Camilli H Goldfine D A Portnoy

A number of bacterial species secrete phosphatidylinositol-specific phospholipase C (PI-PLC). In this report, we show that the facultative intracellular bacterial pathogen, Listeria monocytogenes, contains a gene, plcA, predicting a polypeptide with 31% amino acid identity to a Bacillus thuringiensis PI-PLC. Accordingly, L. monocytogenes secretes PI-PLC activity, while a mutant with a transposo...

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000
S S Bae D K Perry Y S Oh J H Choi S H Galadari T Ghayur S H Ryu Y A Hannun P G Suh

Apoptosis is a cell suicide mechanism that requires the activation of cellular death proteases for its induction. We examined whether the progress of apoptosis involves cleavage of phospholipase C-gamma1 (PLC-gamma1), which plays a pivotal role in mitogenic signaling pathway. Pretreatment of T leukemic Molt-4 cells with PLC inhibitors such as U-73122 or ET-18-OCH(3) potentiated etoposide-induce...

Journal: :Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2000
T Matsui C R Carneiro S C Leão

The genome of Mycobacterium tuberculosis H37Rv contains three contiguous genes (plc-a, plc-b and plc-c) which are similar to the Pseudomonas aeruginosa phospholipase C (PLC) genes. Expression of mycobacterial PLC-a and PLC-b in E. coli and M. smegmatis has been reported, whereas expression of the native proteins in M. tuberculosis H37Rv has not been demonstrated. The objective of the present st...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه سمنان - پژوهشکده برق و کامپیوتر 1393

با ظهور شبکه های dcs و کنترل فازی، برنامه های plc بعنوان ابزاری مناسب برای استفاده از پتانسیل plc ها در مدیریت مصرف انرژی، زمینه حضور فعال plc ها در بهبود عملکرد سیستم های مدیریتی را فراهم آورند. در این پایان نامه عملکرد plc بعنوان عضو اساسی در سیستم مدیریت انرژی با استخراج الگوریتم های بهینه سازی مختلف بعنوان یکی از مهمترین ابزار های مدیریتی کنترل یک کارخانه گچ مدل سازی شده و در اختیار برنامه ...

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