During cell division, microtubules organize a bipolar spindle to drive accurate chromosome segregation to daughter cells. Microtubules are nucleated by the γ-TuRC, a γ-tubulin complex that acts as a template for microtubules with 13 protofilaments. Cells lacking γ-TuRC core components do nucleate microtubules; however, these polymers fail to form bipolar spindles. NEDD1 is a γ-TuRC-interacting ...

Recent studies have demonstrated that kokumi substances, such as glutathione, are perceived through the calcium-sensing receptor (CaSR), and screening by CaSR assay and sensory evaluation has shown that γ-glutamyl-valyl-glycine (γ-Glu-Val-Gly) is a potent kokumi peptide. In this study, the contents of γ-Glu-Val-Gly in six commercial brands of dark-coloured soy sauces, two brands of light-colour...

An efficient and convenient strategy for the enantioselective synthesis of enantiomerically enriched 10-ethyl-7,8-dihydro-γ-ionone isomers (R)-(+)-7, and (S)-(-)-7 are described utilizing a lipase mediated resolution protocol, and reductive elimination of the secondary allylic alcohol as the key step. The enantioselective and diastereoselective lipase kinetic acetylation of 4-hydroxy-γ-ionone d...

The thiazide-sensitive NaCl cotransporter (NCC) plays a key role in renal salt reabsorption and the determination of systemic BP, but the molecular mechanisms governing the regulation of NCC are not completely understood. Here, through pull-down experiments coupled to mass spectrometry, we found that γ-adducin interacts with the NCC transporter. γ-Adducin colocalized with NCC to the distal conv...

In this paper we make a survey of some recent developments of the theory of Sobolev spaces W (X, d,m), 1 < q < ∞, in metric measure spaces (X, d,m). In the final part of the paper we provide a new proof of the reflexivity of the Sobolev space based on Γ-convergence; this result extends Cheeger’s work because no Poincaré inequality is needed and the measure-theoretic doubling property is weakene...

By looking at the Γ-convergence of some easy functionals in terms of underlying Young measures, we emphasize the connection of this issue with the Monge-Kantorovich mass transfer problem. After exploring this relationship, we study a typical example in periodic homogenization to realize the difference between the Monge-Kantorovich problem and the usual cell-problem. We also state a version of t...

We investigate the limiting description for a finite-difference approximation of a singularly perturbed Allen–Cahn type energy functional. The key issue is to understand the interaction between two small length-scales: the interfacial thickness ε and the mesh size of spatial discretization δ. Depending on their relative sizes, we obtain results in the framework of Γ-convergence for the (i) subc...