The alkoxide-catalyzed addition of alcohols 2 to a-chloroacrylonitrile (1) at -35°C gives rise to 3-alkoxy-2-chloropropancnitriles 3; at D-5°C with excess _2 alkyl 3-alkoxy-2-chloropropanicidates 3 are obtained. The yields of 3 or 4 decrease with increasing pK, values of the alcohols 2. In the basecatalyzed addition of phenols 5 to 1, a temperature-dependent addition equilibrium is set up in wh...

An efficient method for molecular iodine catalyzed decarboxylative substitution of β-keto acids with benzylic alcohols under mild conditions has been described and valuable α-functionalized ketones were obtained in good to excellent yields.

An asymmetric 5-endo chloroetherification of homoallylic alcohols is successfully developed that employs an easily available quaternary ammonium salt derived from cinchonine as a conventional organocatalyst. This approach provides ready access to β-chlorotetrahydrofurans in high enantioselectivities.

A highly regioselective protocol for the direct synthesis of γ,δ-unsaturated ketones from β-ketoacids and allylic alcohols was proposed and accomplished relying on the combination of [Ir(cod)Cl]2 and 10-camphorsulfonic acid via decarboxylative allylation.

An unprecedented three-component oxysulfenylation reaction of alkenes with sulfonyl hydrazides and alcohols has been developed in the presence of 20 mol% iodine to give a range of structurally diverse β-alkoxy sulfides in good to excellent yields.

We disclose an organocatalyzed enantioselective decarboxylative ketone aldol reaction of β-ketoacids with trifluoromethyl ketones in the presence of biscinchona alkaloid (DHQD)(2)AQN, affording chiral tertiary alcohols in up to 98% yield and 90% ee.

The photoreactive AMP analog, 8-azido-AMP, stimulated the activity of biodegradative threonine dehydratase of Escherichia coli in a reversible manner and, like AMP, decreased the Km for threonine. The concentrations required for half-maximal stimulation by AMP and 8-azido-AMP were 40 microM and 1.5 microM, respectively, and the maximum stimulation by 8-azido-AMP was 25% of that seen with AMP. G...

Abstract β‐Galactose derivatives have recently been reported to selectively inhibit galectin‐3, and a library of O3‐arylated galactosides with varying substitution patterns was designed study such inhibitions further. The were synthesized using diaryliodonium salts under mild transition metal free conditions, providing the target products in moderate good yields. An O3‐trifluoroethylated galact...

Allylic alcohols and their derivatives are readily available organic compounds that frequently employed in synthesis. These allylic substrates add oxidatively to transition metals form π-allyl metal species, which instantly become nucleophilic under reductive conditions react with various electrophiles including the rather stable CO2 afford synthetically useful β,γ-unsaturated carboxylic acid d...

  The compound 4-Azido-N-(6-chloro-3-pyridazinyl)benzenesulfonamide was synthesized and studied using FTIR, 1H-NMR . influence of a solvent on the experimental chemical shifts title is discussed. Small shift Δδ < 0.1 ppm were observed when switching from DMSO-d6 to CD3OD. Record marked change in valeues > 0.3 transform high-polar solvents (DMSO-d6,and CD3OD)  low-polar (CDCl3). ...