Hyperekplexia is a neurological disorder associated primarily with mutations in the α1 subunit of glycine receptors (GlyRs) that lead to dysfunction of glycinergic inhibitory transmission. To date, most of the identified mutations result in disruption of surface expression or altered channel properties of α1-containing GlyRs. Little evidence has emerged to support an involvement of allosteric G...

Glycine receptors (GlyRs) belong to the superfamily of pentameric cys-loop receptor-operated channels and are involved in numerous physiological functions, including movement, vision, and pain. In search for compounds performing subunit-specific modulation of GlyRs we studied action of ginkgolic acid, an abundant Ginkgo biloba product. Using patch-clamp recordings, we analyzed the effects of gi...

α1-Adrenergic stimulation increases blood vessel tone in mammals. This process involves a number of intracellular signaling pathways that include signaling via phospholipase C, diacylglycerol (DAG), and protein kinase C. So far, it is not certain whether signaling via phospholipase D (PLD) and PLD-derived DAG is involved in this process. We asked whether PLD participates in the α1-adrenergic-me...

The root discriminant of a number field of degree n is the nth root of the absolute value of its discriminant. Let R0(2m) be the minimal root discriminant for totally complex number fields of degree 2m, and put α0 = lim infmR0(2m). Define R1(m) to be the minimal root discriminant of totally real number fields of degree m and put α1 = lim infmR1(m). Assuming the Generalized Riemann Hypothesis, α...

Wediscuss various questions around partitioning a split graph into connected parts. Our main result is a polynomial time algorithm that decides whether a given split graph is fully decomposable, that is, whether it can be partitioned into connected parts of orders α1, α2, . . . , αk for every α1, α2, . . . , αk summing up to the order of the graph. In contrast, we show that the decision problem...

Abstract. Recently Breaz and Breaz [4] and Breaz et.al[5] introduced two general integral operators Fn and Fα1,...,αn . Considering the classes N(γ), MT(μ, β) and KD(μ, β) we derived some properties for Fn and Fα1,...,αn . Two new subclasses KDFn(μ, β, α1, ..., αn) and KDFα1,...,αn(μ, β, α1, ..., αn) are defined. Necessary and sufficient conditions for a family of functions fj to be in the KDFn...

Background: Most studies show that 9 to 24% of people who are in in vitro fertilization (IVF) cycles are women who respond poorly to ovarian stimulation. Women with poor ovarian response (POR) are a group of infertile patients whose ovarian reserve, ovarian response to medication, and the quality of ovum are declining. Therefore, the number of female cycles, the number of fetuses from the oocyt...

Diabetic nephropathy is a major complication of diabetes mellitus (DM). Recent studies suggest that immunological mechanisms have a key role in the pathogenesis of DM, therefore these mechanisms may be important targets for diabetes therapy. The present study evaluated the effects of anti-α1-adrenergic receptor antibody (α1-R Ab) mediation and doxazosin treatment in a rat model of DM. It was ob...

BACKGROUND Fungal mating types in self-incompatible Pezizomycotina are specified by one of two alternate sequences occupying the same locus on corresponding chromosomes. One sequence is characterized by a gene encoding an HMG protein, while the hallmark of the other is a gene encoding a protein with an α1 domain showing similarity to the Matα1p protein of Saccharomyces cerevisiae. DNA-binding H...

Liprin-α1 and ERC1 are interacting scaffold proteins regulating the motility of normal and tumor cells. They act as part of plasma membrane-associated platforms at the edge of motile cells to promote protrusion by largely unknown mechanisms. Here we identify an amino-terminal region of the liprin-α1 protein (liprin-N) that is sufficient and necessary for the interaction with other liprin-α1 mol...