The present study offers results of analysis concerning the course of reaction between reduced α-lipoic acid (LA) and 2-chloro-1-methylquinolinium tetrafluoroborate (CMQT). In water environments, the reaction between CMQT and hydrophilic thiols proceeds very rapidly and the resultant products are stable. For the described analysis, optimum reaction conditions, such as concentration of the reduc...

background neuropathy is one of the most complications of diabetes that may be associated with changes in the structure and function of the basement membranes in nerves. laminin is one of the most important components of basement membranes in sciatic nerve. objectives in this study, the protective effects of alpha lipoic acid (ala) as an antioxidant agent on blood glucose level, body weight and...

Radiation-induced fibrosis (RIF) is one of the most common late complications of radiation therapy. We found that α-lipoic acid (α-LA) effectively prevents RIF. In RIF a mouse model, leg contracture assay was used to test the in vivo efficacy of α-LA. α-LA suppressed the expression of pro-fibrotic genes after irradiation, both in vivo and in vitro, and inhibited the up-regulation of TGF-β1-medi...

abstractintroduction: majority of diabetic patients eventually develop hypertension. becase of its antioxidative properties, alpha-lipoic acid plays an effective role in decreasing oxidative stress and preventing endothelium dysfunction. the purpose of the present study was to determine the effect of alpha-lipoic acid on blood pressure in type 2 diabetic patients. materials & methods: fifty-sev...

To thrive in diverse environments, bacteria must shift their metabolic output in response to nutrient bioavailability. In many bacterial species, such changes in metabolic flux depend upon lipoic acid, a cofactor required for the activity of enzyme complexes involved in glycolysis, the citric acid cycle, glycine catabolism, and branched chain fatty acid biosynthesis. The requirement of lipoic a...

Title: (R)-α-Lipoic acid inhibits fructose-induced myoglobin fructation and the formation of advanced glycation end products (AGEs) in vitro Authors: Hardik Ghelani ([email protected]) Valentina Razmovski-Naumovski ([email protected]) Rajeswara Pragada ([email protected]) Srinivas Nammi ([email protected]) Version: 1 Date: 18 Nov 2017 Author’s response t...

The role that antioxidants play in the process of carcinogenesis has recently gained considerable attention. alpha-Lipoic acid, a naturally occurring disulfide molecule, is a powerful antioxidant that reportedly exerts beneficial effects in patients with advanced cancer by reducing the level of reactive oxygen species and increasing glutathione peroxidase activity. In this study, we examined ch...