نتایج جستجو برای: α endosulfan
تعداد نتایج: 165679 فیلتر نتایج به سال:
Endosulfan-alpha is metabolized to a single metabolite, endosulfan sulfate, in pooled human liver microsomes (Km = 9.8 microM, Vmax = 178.5 pmol/mg/min). With the use of recombinant cytochrome P450 (P450) isoforms, we identified CYP2B6 (Km = 16.2 microM, Vmax = 11.4 nmol/nmol P450/min) and CYP3A4 (Km = 14.4 microM, Vmax = 1.3 nmol/nmol P450/min) as the primary enzymes catalyzing the metabolism ...
Endosulfan (6,7,8,9,10,10-hexachloro-1,5,5a,6,9,9a-hexahydro6,9-methano-2,4,3-benzo-odioxa-thiepin-3-oxide) is a chlorinated cyclodiene insecticide which acts as a contact poison in a wide variety of insects and mites (Naqvi and Vaishnavi, 1993). Endosulfan was first registered for use in the USA in 1954 to control agricultural insects and mite pests. Due to its toxic effect, the World Health O...
Endosulfan is an organochlorine insecticide and acaracide used to control a broad range of insect and arthropod pests on a wide variety of crops in many agrosystems. It can cause acute and chronic toxicity. Endosulfan is a neurotoxin, haematoxin, genotoxin and nephrotoxin. Toxicity of this insecticide on reproductive organs is confirmed. So this article reviews experimental and epidemiological ...
The genotoxic effect of endosulfan and the modulatory effect of vitamin C in growing albino rats were studied by bone marrow micronucleus assay. Seven days old male Wistar rats were treated with 3, 6, 9, 12mg/kg Endosulfan orally (10 pups/group),for up to 60 days, at intervals of 24h. For 2 more groups (n=10/group), Endosulfan 9mg/kg and 12mg/kg was administered along with vitamin C (20mg/kg). ...
The levels of dichlorodiphenyltrichloroethane (DDT), dichlorodiphenyldichloroethylene (DDE), endosulfan, endosulfan sulfate, carbofuran, and cartap which were estimated in the flesh of Catla catla sampled from ten sites of Ravi River between its stretches from Shahdara to Head Balloki were studied to know the level of contamination of the selected pesticides by GC-ECD method. All fish samples w...
The increasing knowledge of the reproductive toxicity of environmental chemicals has raised public concern as to whether the current use of pesticides could adversely affect human reproduction. Among pesticides and their related chemicals, organochlorine insecticides have so far drawn the primary attention. Endosulfan is widely used pesticide due to its quick effect on insects. Endosulfan formu...
A multiresidue analytical methodology based on a solid-phase microextraction (SPME), followed by gas chromatography-ion trap mass spectrometry (GC–IT/MS), has been developed for trace analysis of 20 known or suspected endocrine-disrupting pesticides. The SPME conditions are optimized considering several key parameters to obtain the maximum sensitivity. After optimization, method validation is p...
In this study, the toxicity of endosulfan sulfate, the primary degradation product of the insecticide endosulfan, was determined in three life stages of the grass shrimp (Palaemonetes pugio). After 96 h exposure to endosulfan sulfate, the grass shrimp adult LC50 was 0.86 microg/L (95% CI 0.56-1.31), the grass shrimp larvae LC50 was 1.64 microg/L (95% CI 1.09-2.47) and the grass shrimp embryo LC...
The Erwinia ligand-gated ion channel (ELIC) is a bacterial homologue of vertebrate Cys-loop ligand-gated ion channels. It is activated by GABA, and this property, combined with its structural similarity to GABA(A) and other Cys-loop receptors, makes it potentially an excellent model to probe their structure and function. Here we characterise the pharmacological profile of ELIC, examining the ef...
Organochlorine pesticides are one of the major groups of chemicals responsible for environmental contamination. Endosulfan a pesticide used mainly in cashew plantation is a highly toxic endocrine disrupter and a contact stomach poison. To study the endosulfan degrading microorganisms, 20 soil samples were collected from five different cashew plantations having a history of endosulfan applicatio...
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