Mechanisms for resistance were studied in three classic type, human small cell lung cancer cell lines, (.!(,,, (.I.(',„,and <;i.<',.i, that were established from one patient during clinical follow-up. Clinically the tumor changed from sensitive (<;!,(,,) to completely resistant to (chemo)therapy ((il.(.',,,) during this period. The stain with JSB-1 anti body, detecting the M, 170,000 multidru...

â â â  â â â â â  abstract â  the research on social networks and collaborative strategies has highlighted from the mid of 1980 which has contributed to the success and development of firms. the relationship and communication with trade partners in overseas help success of firms in entering to foreign markets and improve new partners and new markets abroad. doing firm internationalization in fo...

Several human monoclonal antibodies directed to tumor-associated glycolipid antigens have been established, but more than one-half of them react with gangliosides and the others react with neutral glycolipids. We report here the first establishment of a human IgM monoclonal antibody directed to the sulfated glycolipid. This monoclonal antibody, M14-376, did not react with SM<and Sm„ which hav...

To elucidate the significance of tRNA modification for human lymphoid maturation and malignant transformation, the amount of tRNAs having guanosine in place of queuosine, i.e., (Q-)tRNA, was determined in several human lymphomas and leukemias by exchanging the respective unmodified guanosine residue for [3H]guanine, a reaction catalyzed by a specific tRNA transglycosylase from Escherichia coli....

To elucidate the significance of tRNA modification for human lymphoid maturation and malignant transformation, the amount of tRNAs having guanosine in place of queuosine, i.e., (Q-)tRNA, was determined in several human lymphomas and leukemias by exchanging the respective unmodified guanosine residue for [3H]guanine, a reaction catalyzed by a specific tRNA transglycosylase from Escherichia coli....

Cholecystokinin (CCK) is a growth factor for normal pancreas. Nu merous studies also suggest that CCK promotes pancreatic carcinogenesis in the rat. Our previous studies suggested that growth of preneoplastic pancreatic foci was stimulated by CCK more than that of normal pan creas. We hypothesized that such differential growth might be due to increased numbers of CCK receptors in neoplastic tis...

The 0-24-h urinary metabolic profile of cyclophosphamide was inves tigated in a series of 14 patients with various malignancies receiving combination chemotherapy including i.v. cyclophosphamide. This was accomplished using combined thin-layer chromatography-photographydensitometry, which can quantitate cyclophosphamide and its four prin cipal urinary metabolites (4-ketocyclophosphamide, nor-ni...

Recently, evidence was reported for the belief that a carcinogenic agent, †̃20-methyleholanthrene, could be secreted into the milk of a lactating ani mal and thereby gain entrance into the bodies of the offspring to cause an abnormally high mci dence of neoplasms (1). Further positive evidence for this mode of excretion of methyleholanthrene has now been obtained by means of ultraviolet ab sor...

semantics: k-CFA ((f e), β̂, σ̂, â) ; (e′, β̂′, σ̂′, â′), where Ê(f, β̂, σ̂) ∋ 〈(λ (x) e′), β̂′′〉 â′ = ⌊l · â⌋k Ê(e, β̂, σ̂) = d̂ β̂′ = β̂′′[x 7→ â′] σ̂′ = σ̂ ⊔ [â′ 7→ d̂] And: Ê(x, β̂, σ̂) = σ̂(β̂(x)) Ê((λ (x) e), β̂, σ̂) = {〈(λ (x) e), β̂〉} Resolving and Exploiting the k-CFA Paradox, New England Programming Language and Systems Sysmposium, MIT, December, 2009 – p.5/22 The Paradox of k-CFA Resolving and Exploiting ...

We optimized the modulation of drug resistance by the irreversible augmentation of cytotoxicity of coincubating vinblastine (VNB) with VP16 and the reversible increase in cytotoxicity of coincubation of verapamil (VPL) with VNB and VP-16. VPL was administered as a loading dose (i.v.) (0.15 mg/kg) and then administered as a constant infusion (0.005 mg/kg) over 6 days. 24 h after verapamil, VNB 2...