the internal mammary artery (ima) is currently the preferred conduit for myocardial revascularization. however, pre-operative vasospasm and a hypoperfusion state during maximal exercise may limit its use as a bypass graft. the mechanism of spasm has not been clearly defined. since β-adrenoceptor activation plays a major role in vasorelaxation, the present study was carried out to investigate th...

BACKGROUND Few studies have systematically investigated insomnia in adults with epilepsy. METHODS We performed a prospective cross-sectional investigation of the prevalence, severity, and comorbidities of insomnia in 90 adults with epilepsy using a battery of self-reported instruments and polysomnography. We quantified insomnia severity using the Insomnia Severity Index (ISI). RESULTS Fifty...

-Adrenoceptors contribute to hypertension in spite of the fact that -adrenoceptor agonists lower blood pressure. We aimed to differentiate between these functions and to identify differences between spontaneously hypertensive and normotensive rats. -Adrenoceptor antagonists with different subtype selectivity or the ability to cross the blood-brain barrier were used to demonstrate -adrenoceptor ...

The Wnt/ß-catenin signaling pathway controls important cellular events during development and often contributes to disease when dysregulated. Using high throughput screening we have identified a new small molecule inhibitor of Wnt/ß-catenin signaling, WIKI4. WIKI4 inhibits expression of ß-catenin target genes and cellular responses to Wnt/ß-catenin signaling in cancer cell lines as well as in h...

The reporter gene for ß-galactosidase is frequently used to determine the efficiency of gene transfer in arteries. However, blood is often present in arterial explants and may compromise the results by the presence of hemoglobin. The light absorption of hemoglobin is similar to the absorption of several colorimetric products of the commonly used ß-galactosidase substrates, including onitropheny...

Bu çalışmanın amacı, Spor Bilimleri Fakültesinde (SBF) öğrenim gören öğrencilerin, öğrenme stili tercihleri ve öz kontrollü durumlarının akademik başarılarına etkisini araştırmaktır. Nicel araştırma yöntemlerinden, ilişkisel tarama modelinin kullanıldığı araştırmanın çalışma grubunu, SBF’de 2021-2022 yılda gören, kolay örnekleme yöntemi ile seçilen 348 gönüllü öğrenci oluşturmuştur. Çalışmada v...

Background: Magnetic resonance imaging (MRI) is becoming increasingly important in axial spondyloarthritis (SpA) due to its unique role early diagnosis, classification, and monitoring of disease (1, 2). It the only assessment tool that has been validated with histological inflammatory cellularity tissue biopsy sacroiliac (SI) joint (3). However, many MRI lesions are not exclusive SpA may occur ...

Understanding the antibiotic susceptibility of Salmonella enterica is important both from a clinical treatment and a public health perspective. The emergence of extended spectrum ß-lactamases (ESßLs) and AmpC ß-lactamases in S. enterica is important, as this will limit treatment options and could provide a strain with a significant selective advantage. The aim of the study was to screen isolate...

Odontogenic keratocyst is now designated by the World Health Organization as a keratocystic odontogenic tumor (KCOT). According to recent reports Wnt pathway and ß-catenin are involved in the pathogenesis of the majority of odontogenic and neoplastic lesions. The aim of this study was to evaluate the expression of ß-catenin in KCOT and compare it with those of dentigerous cyst and ameloblastoma...

The proper localization of ß-actin mRNA and protein is essential for growth cone guidance and axon elongation in cultured neurons. In addition, decreased levels of ß-actin mRNA and protein have been identified in the growth cones of motor neurons cultured from a mouse model of Spinal Muscular Atrophy (SMA), suggesting that ß-actin loss-of-function at growth cones or pre-synaptic nerve terminals...