Morphogenesis is crucial to initiate physiological development and tumor invasion. Here we show that a microRNA controls zonation morphogenesis by targeting hyaluronan receptor CD44. We have developed a novel system to study microRNA functions by generating constructs expressing pre-miRNAs and mature miRNAs. Using this system, we have demonstrated that expression of miR-328 reduced cell adhesio...

The hepatic lobule is divided into three zones along the portal-central vein axis. Hepatocytes within each zone exhibit a distinctive gene expression profile that coordinates their metabolic compartmentalization. The zone-dependent heterogeneity of hepatocytes has been hypothesized to result from the differential degree of exposure to oxygen, nutrition and gut-derived toxins. In addition, the g...

Landslides are the most common natural hazard in Piemonte region (northwestern Italy). This study is focused on shallow landslides caused by sliding of surficial detrital-colluvial cover rainfall and characterized a sudden fast evolution. investigates landslide events compared with variables considered as main predisposing qualitative factors (lithology, pedology land use) to obtain zonation su...

Early diagenetic modification of magnetic properties is an important process in marine sediments, but temporal and spatial variability of diagenetic processes have rarely been reported for recent coastal sediments. The magnetic properties of sediments from the Ria de Vigo (NW Spain) define a marked three-part zonation with depth. The uppermost zone is magnetically dominated by (titano-)magnetit...

This paper presents an approach for rapid assessment of sustainability for Mainland China based on a multilayer index system. Efficient assessment is conducted with the basic mapping units at county and city levels. After evaluating a comprehensive sustainable development index, SDI, for each unit, five rankings of sustainability are determined, and a zonation map produced. Regional characteris...

conflagration of forests and rangelands is one of the most frequent events in iran. it is regarded as one of the most important parts of land degradation that occurred due to range destruction and desertification. this study was conducted in boroujerd, lorestan province in west of iran in 2013 to determine the fire risk model. the data prepared for the study area involved the vegetation types, ...

[1] Apatite He/He thermochronometry has the potential to constrain cooling histories for individual samples provided that several presently untested assumptions are valid. Here we simulate the sensitivity of He/He spectra to assumptions regarding geometric model, crystallographic anisotropy, broken grain terminations, parent nuclide zonation, and the accuracy of results obtained from analyses o...

The rapid spread and diversification of outdoor recreation can impact on wildlife in various ways, often leading to the avoidance of disturbed habitats. To mitigate human-wildlife conflicts, spatial zonation schemes can be implemented to separate human activities from key wildlife habitats, e.g., by designating undisturbed wildlife refuges or areas with some level of restriction to human recrea...

Although typically small in terms of their spatial footprint, landslide hazards are relatively frequent in Northern Iran. In this study, we combine Geographic Information System (GIS), remote sensing and derive a landscape susceptibility map for Bostan Abad County, Iran. The main objective is an inventory evaluation and zonation of natural landslides. This 2685 square kilometer sized county is ...