3,7,23,27-Tetrabromo[36]octaphyrin 2 was synthesized as a novel octaphyrin bearing two meso-free positions. Surprisingly, its ZnII and NiII complexation reactions produced directly fused porphyrin(2.1.1.1) dimer 6, meso-α N-confused porphyrin (NCP) 7, the first example of NCP tape, respectively, via transannular C−C bond formation. While 6 exhibits diatropic ring-current effect owing to global ...

Mutations in the metalloprotein Cu,Zn-superoxide dismutase (SOD1) cause approximately 20% of familial cases of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease for which effective therapeutics do not yet exist. Transgenic rodent models based on over-expression of mutant SOD1 have been developed and these have provided opportunity to test new therapeutic strategies and to s...

A number of multiresistant bacterial pathogens inactivate antibiotics by producing Zn(II)-dependent β-lactamases. We show that metal uptake leading to an active dinuclear enzyme in the periplasmic space of Gram-negative bacteria is ensured by a cysteine residue, an unusual metal ligand in oxidizing environments. Kinetic, structural and affinity data show that such Zn(II)-cysteine interaction is...

Recently, we demonstrated that AgI can directly replace ZnII in zinc fingers (ZFs). The cooperative binding of to ZFs leads a thermodynamically irreversible formation silver clusters destroying the native ZF structure. Thus, reported loss biological function proteins is likely consequence such replacement. Here, report an X-ray absorption spectroscopy (XAS) study AgnSn formed probe their struct...

By their conformational flexibility, Möbius aromatic hexaphyrins provide a dynamic chirality attractive to develop stimuli responsive systems such as chiroptical switches. A regular [28]hexaphyrin has been equipped with chiral coordinating arm achieve transfer of from fix stereogenic element the one. The allows straightforward formation labile monometallic ZnII complexes an exogenous ligand, ei...

Three new ionic salts containing [M(CN)8]4? (M = MoIV and WIV) were prepared using large complex cations based on a non-conventional motif built with the tris(2-aminoethyl)amine (noted hereafter tren) ligand, [{M’(tren)}3(?-tren)]6+ (M’ CuII ZnII). The crystal structures of three compounds show that atomic arrangement is formed by relatively isolated anionic cationic entities. irradiated blue l...