نتایج جستجو برای: zinc metalloprotease
تعداد نتایج: 76334 فیلتر نتایج به سال:
Shiga toxin-producing Escherichia coli (StEC) cause hemorrhagic colitis (hC) and hemolytic uremic syndrome (hUS) in humans. Outbreaks are linked to bovine food sources. While StEC O157:h7 has been responsible for the most severe outbreaks worldwide, non-O157 serotypes have emerged as important enteric pathogens in several countries. the main virulence factor of StEC is the production of Shiga t...
Thiolutin is a disulfide-containing antibiotic and anti-angiogenic compound produced by Streptomyces. Its biological targets are not known. We show that reduced thiolutin is a zinc chelator that inhibits the JAB1/MPN/Mov34 (JAMM) domain-containing metalloprotease Rpn11, a deubiquitinating enzyme of the 19S proteasome. Thiolutin also inhibits the JAMM metalloproteases Csn5, the deneddylase of th...
treat acquired immunodeficiency syndrome [AIDS]) and against the angiotensin-converting enzyme (ACE) (to treat hypertension) are the only protease inhibitors approved by the FDA for therapeutic use (see Table 1). HIV-1 protease is an aspartic protease that is necessary for the processing of viral polypeptides late in the viral replicative cycle. Inhibition of this activity prevents formation of...
The LIV-1 gene has been previously associated with oestrogen-positive breast cancer and its metastatic spread to the regional lymph nodes. We have investigated the protein product of this gene as a marker for disease progression of breast cancer. The protein sequence contains a potential metalloprotease motif (HEX P H E XGD), which fits the consensus sequence for the catalytic zinc-binding site...
Clostridium difficile is a major cause of infectious diarrhea worldwide. Although the cell surface proteins are recognized to be important in clostridial pathogenesis, biological functions of only a few are known. Also, apart from the toxins, proteins exported by C. difficile into the extracellular milieu have been poorly studied. In order to identify novel extracellular factors of C. difficile...
The extreme radiation resistance of Deinococcus bacteria requires the radiation-stimulated cleavage of protein DdrO by a specific metalloprotease called IrrE. DdrO is the repressor of a predicted radiation/desiccation response (RDR) regulon, composed of radiation-induced genes having a conserved DNA motif (RDRM) in their promoter regions. Here, we showed that addition of zinc ions to purified a...
The psychrophilic alkaline metalloprotease (PAP) produced by a Pseudomonas bacterium isolated in Antarctica belongs to the clan of metzincins, for which a zinc ion is essential for catalytic activity. Binding studies in the crystalline state have been performed by X-ray crystallography in order to improve the understanding of the role of the zinc and calcium ions bound to this protease. Cocryst...
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