In vitro release kinetics of three commercially available sustained release tablets (SR) diltiazem hydrochloride were studied at pH 1.1 for 2 h and for another 6 h at pH 6.8 using the USP dissolution apparatus with the paddle assemble. The kinetics of the dissolution process was studied by analyzing the dissolution data using five kinetic equations: the zero-order equation, the first-order equa...

nonexchangeable soil-k release rate can significantly affect k dynamics and it's bioavailability during plant growth. in this study, twelve soil samples taken from different wheat cropping regions of iran were incubated with nabph4 to (i) investigate the kinetics of nonexchangeable k release and (ii) to compare the ability of various kinetic equations (zero-, first- and second-order, parab...

Thymol, an important and advantageous component of many essential oils, has been applied as an antimicrobial agent in animals. To increase the duration of action of this compound in ruminants, it was decided here to prepare a controlled release carrier for thymol. Hydroxy propyl methyl cellulose (HPMC) and ethyl cellulose (EC) were used as the matrix polymer here. Mixtures of thymol with eight ...

M. S. DHANOA , S. LÓPEZ *, R. SANDERSON 1 AND J. FRANCE 3 1 Institute of Grassland and Environmental Research (IGER)#, Plas Gogerddan, Aberystwyth, Ceredigion, SY23 3EB, UK 2 Instituto de Ganaderı́a de Montaña (IGM), Universidad de León – Consejo Superior de Investigaciones Cientı́ficas (CSIC ), Departamento de Producción Animal, Universidad de León, E-24071 León, Spain 3Centre for Nutrition Mode...

objective (s): mucoadhesive disc is one of the various routes of drug delivery for curing buccal disease.materials and methods:everydiscs containing 70 mg stem bark extract of ziziphus jujuba were formulated  by using carbopol 934, pvp k30 and gelatin as polymers. discs were made by granulation  and direct compression. discs were standardized based on the total phenol.  properties such as in vi...

Acute respiratory infection (ARI) is a that causes disruption of normal activities. Amoxicillin the antibiotic first choice generally given to patients with ARI. Compliance in use antibiotics for less than five days will determine success therapy so frequency drug also affects patient compliance taking medication. Granule mucoadhesive amoxicillin trihydrate formula designed addition chitosan po...

As an alternative to the particle tracking-based residence time calculations, a finite difference approach using the conventional advection-diffusion-reaction kinetics equation for describing the evolution of the residence time field is derived. Advection and mixing of water masses is accompanied with their ageing following a simple zero-order kinetics rule. The governing equations are solved b...

The objective of the present study was to develop sustained release oral matrix tablets of anti epileptic drug levetiracetam. The sustained release matrix tablets of levetiracetam were prepared using hydrophilic matrix hydroxypropyl methylcellulose (HPMC) as a release retarding polymer by wet granulation method. Prior to compression, FTIR studies were performed to understand the compatibility b...

The objective of this study was to develop a sustained release matrix tablet Metoprolol Succinate by cost saving and production efficient process. Among various tablet manufacturing process, direct compression is the simplest and cost saving process. Different trials were formulated and evaluated using different concentrations of directly compressible grade Kollidon SR as release retardant. The...