We present the case of a patient that progressively developed xerophthalmia, xerostomia, cutaneous xerosis and exocrine pancreatic insufficiency 3 months after metamizole-induced toxic epidermal necrolysis. Though the association of Sjögren's syndrome and exocrine pancreatic impairment is well established, the Sjögren-like syndrome after drug-induced toxic epidermal necrolysis in association wi...

A 45-year-old-man presented with severe vomiting, constipation, abdominal distention and bilateral ocular abductor palsy. Evaluation revealed diffuse autonomic dysfunction characterized by intestinal pseudo-obstruction, xerophthalmia, xerostomia, postural hypotension, erectile dysfunction and loss of sinus arrhythmia. Paraneoplastic work-up revealed thymoma. Most symptoms resolved after surgica...

In 11 patients with active corneal xerophthalmia, conjunctival biopsies were obtained at various intervals after massive-dose systemic vitamin A therapy. Goblet cells began to repopulate the inferonasal quadrant of the conjunctivas after two weeks, and they reached normal concentrations after one month. Corneal healing proceeded much more rapidly than that, suggesting that a full complement of ...

beings are poor growth, night blindness, xerophthalmia, keratomalacia, phrynoderma, decreased resistance to all infective diseases in general and to respiratory disease in particular. The main sources of the vitamin for human beings in their normal dietary are milk, butter, ghee, eggs, liver-meat, fish and green leafy vegetables. Vegetables do not contain vitamin A as such, but in the form of c...

OBJECTIVES To determine the prevalence and causes of the blindness and ocular morbidity amongst Sudanese refugees; to prioritise and provide eye care services to the refugees and; to device administrative strategies and logistics of prevention and control of blinding diseases among the refugees. DESIGN A mobile outreach clinic study for six weeks. SETTING Adjumani settlement camps for Sudan...

We report a case of hypokalaemic quadriparesis in 31-year old woman in whom the discovery of distal renal tubular acidosis led to the diagnosis of primary Sjögren's syndrome. Hypokalaemic paralysis as initial manifestation of primary Sjögren's syndrome is rare, but when it occurs it may precede symptoms of xerostomia and xerophthalmia. The diagnosis of primary Sjögren's syndrome should be consi...

It is vitally important to realise that many children who are vitamin A deficient will not have the eye signs, known as xerophthalmia (dry eye). This means that children with the eye signs are only the ‘tip of the iceberg’ – there will be many other children in the community who are vitamin A deficient but who have completely normal eyes and vision. This is why community approaches to control a...