OBJECTIVE Toxic epidermal necrolysis (TEN) is a rare but life-threatening disease of the skin and mucous membranes. We report our experience in the treatment of pediatric TEN patients with early debridement of necrotic skin and coverage with human allograft skin. METHODS From 1984 to 2000, 15 children (6 girls, 9 boys, 7.2 +/- 1.5 years) with a histologic diagnosis of TEN and involvement of >...

Although debridement is an essential part of wound care, information to guide evidence-based decisions is limited in the literature. Assuming studies to ascertain the effectiveness of pharmaceutically based enzymatic debridement products are more prolific than studies using nonpharmaceutical debridement options, a literature review was conducted to provide an evidence base to justify current wo...

Maggots were used as adjunct treatment for infected wounds that showed no response to the classical approach of wound debridement and antibiotic therapy. We summarize findings for 11 patients with necrotic wounds who received treatment with "surgical" maggots (100-2900 applied in 3-10 changes of dressing) for 11-34 days, which apparently aided in tissue remodeling and cure, and describe 2 typic...

Pedicle omentum transfer has been used for the treatment of human tissue trauma. Eight large skin wound cases of 6-10 months, 5kg-10kg body weight, hybrid local dogs were chosen and medially divided into two groups. Every group had four cases including two males and two females. The size of all skin wound surface on abdominal wall were approximately 5cm×5cm. One group were reshaped as “H” satur...

Second session — Results of the European RCT 'Earth study': Sylvie Meaume, MD, GerontologistDermatologist, Head of the Clinical Gerontology Department, Wound Care Unit, Hospital Rothschild APHP, University of Paris, UPMC, France The second session focused on the role of dressings in wound desloughing. The study by Sylvie Meaume et al (2014)[5] on ‘Evaluation of two fibrous wound dressings for t...

The three main considerations for optimal wound bed preparation are regular debridement to reduce devitalised tissue and encourage formation of healthy granulation tissue, restoration of bacterial balance and promotion of a moist wound-healing environment through exudate management (Schultz et al, 2003). Honey provides a moist wound-healing environment, and is antimicrobial, de-odourising, anti...

Pulsatile lavage is a high-pressure irrigation treatment commonly used in the debridement of wounds. The risk of exposure to bloodborne pathogens and contaminants using high-pressure irrigation has been well documented in the literature. Projectile droplets and aerosolized fine droplets may form and spread, potentially contaminating the treatment facility and infecting personnel. A new devic...

This article builds and expands upon the concept of wound bed preparation introduced by Sibbald et al in 2000 as a holistic approach to wound diagnosis and treatment of the cause and patient-centered concerns such as pain management, optimizing the components of local wound care: Debridement, Infection and persistent Inflammation, along with Moisture balance before Edge effect for healable but ...

Sternal wound infection is a life-threatening complication after cardiac surgery associated with high morbidity and mortality. Past treatment options have included closed suction and continuous irrigation. Current paradigms in the management of sternal wound infection include surgical debridement, vacuum-assisted closure therapy, flap coverage, and sternal plating. We provide a general overview...

BACKGROUND Matrix metalloproteinases (MMPs) are crucial in the inflammatory and remodeling phases of wound healing. We previously reported the correlation between pro-inflammatory cytokines and timing of successful combat-wound closure. We now extend our studies to investigate the correlation between wound-remodeling MMP expression and wound healing. METHODS Thirty-eight wounds in 25 patients...