Kinases regulate cell growth, movement, and death. Deregulated kinase activity is a frequent cause of disease. The therapeutic potential of kinase inhibitors has led to large amounts of published structure activity relationship (SAR) data. Bioactivity databases such as the Kinase Knowledgebase (KKB), WOMBAT, GOSTAR, and ChEMBL provide researchers with quantitative data characterizing the activi...

Kinases regulate cell growth, movement, and death. Deregulated kinase activity is a frequent cause of disease. The therapeutic potential of kinase inhibitors has led to large amounts of published structure activity relationship (SAR) data. Bioactivity databases such as the Kinase Knowledgebase (KKB), WOMBAT, GOSTAR, and ChEMBL provide researchers with quantitative data characterizing the activi...

The natural distribution of the critically endangered northern hairy-nosed wombat (Lasiorhinus krefftii) is confined to Epping Forest National Park, Queensland; however, a small number animals have been translocated establish an insurance population at Richard Underwood Nature Refuge (RUNR), Queensland. Northern behaviour poorly understood, mostly due its cryptic behaviour. Thirty-two wildlife ...

An empirical scheme to evaluate and prioritize screening hits from high-throughput screening (HTS) is proposed. Negative scores are given when chemotypes found in the HTS hits are present in annotated databases such as MDDR and WOMBAT or for testing positive in toxicity-related experiments reported in TOXNET. Positive scores were given for higher measured biological activities, for testing nega...

Little is known of the prevalence and life-cycle of trypanosomes in mammals native to Australia. Native Australian trypanosomes have previously been identified in marsupials in the eastern states of Australia, with one recent report in brush-tailed bettongs (Bettongia penicillata), or woylie in Western Australia in 2008. This study reports a novel Trypanosoma sp. identified in blood smears, fro...

First lactation production records of 7,825 Mehsana buffaloes, sired by 200 sires maintained at DudhsagarResearch and Development Association, Dudhsagar Dairy, over a period 25 years (1989-2013), wereutilised for estimation breeding value the first milk yield using BLUP - Univariate sire model andanimal WOMBAT software. The study aimed to find out optimum number daughters that maybe sufficient ...