The objective of this work was to test the hypothesis that endurance training may be protective against in vivo doxorubicin (DOX)-induced cardiomyopathy through mitochondria-mediated mechanisms. Forty adult (6-8 wk old) male Wistar rats were randomly divided into four groups (n = 10/group): nontrained, nontrained + DOX treatment (20 mg/kg), trained (14 wk of endurance treadmill running, 60-90 m...

Endurance training has been shown to increase pancreatic β-cell function and mass. However, whether exercise modulates β-cell growth and survival pathways signaling is not completely understood. This study investigated the effects of exercise on growth and apoptotic markers levels in rat pancreatic islets. Male Wistar rats were randomly assigned to 8-wk endurance training or to a sedentary cont...

the aim of the present study was to investigate the effect of endurance training on syd gene expression in motor neurons of rats with diabetic neuropathy. 12 wistar male rats were randomly assigned to 3 groups (each group 4 subjects): diabetic trained (dt), diabetic untrained (dc) and healthy control (hc). two weeks after stz injection to induce diabetes, diabetic neuropathy was demonstrated by...

Despite the preventative and therapeutic effects of regular exercise, exhaustive exercise may be harmful to health. The present study aimed to determine the protective effect of endurance training and cinnamon bark extract (CBE) supplementation on oxidative responses induced by an exhaustive exercise schedule in rats. The rats were randomly divided into the following five groups of 6; control s...

Habouzit E, Richard H, Sanchez H, Koulmann N, Serrurier B, Monnet R, Ventura-Clapier R, Bigard X. Decreased muscle ACE activity enhances functional response to endurance training in rats, without change in muscle oxidative capacity or contractile phenotype. J Appl Physiol 107: 346–353, 2009. First published April 30, 2009; doi:10.1152/japplphysiol.91443.2008.—In the present study, we tested the...

Recent research suggests that LKB1 is the major AMP-activated protein kinase kinase (AMPKK). Peroxisome-proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) is a master coordinator of mitochondrial biogenesis. Previously we reported that skeletal muscle LKB1 protein increases with endurance training. The purpose of this study was to determine whether training-induced increases ...

Purpose We investigated the effects of endurance training on the expression of long-chain fatty acid transport proteins in the skeletal muscle and whole-body fat oxidation during endurance exercise. Methods Seven-week-old male ICR mice (n = 12) were divided into 2 groups, namely, Sed (sedentary; non-trained) and Tr (endurance-trained) groups. The Tr group was adapted to treadmill training at ...

Study I. Participants were 43 Navy men (mean age = 32.1 yr) assigned to one of three exercise training protocols: aerobic/circuit weight training performed at either 40 or 60% of determined one-repetition maximum strength or aerobic/calisthenic training. During the 10-wk study, each exercise group participated in three training sessions per week performed on alternate days. The results of this ...