نتایج جستجو برای: wiskott
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Infectious Common HIV/AIDS Typhoid fever Babesiosis Malaria Uncommon Viral hepatitis Tuberculosis Histoplasmosis Brucellosis Noninfectious Common Sarcoidosis Chronic corticosteroid use Antilymphocyte globulin Cancer chemotherapy Radiation therapy Rheumatoid arthritis Systemic lupus erythematosus Hodgkin’s disease Chronic alcohol abuse Uncommon CD4 lymphocytopenia Severe combined immunodeficienc...
The VCA domain of the neuronal Wiskott-Aldrich syndrome protein (N-WASP) is a potent activator of the Arp2/3 complex, a 240 kDa heteroheptameric actin-nucleating assembly. We used site-directed spin labeling of N-WASP peptides in conjunction with methyl-TROSY spectra of the intact, selectively labeled Arp2/3 complex to identify regions of the VCA that are proximal to the ARPC3 subunit of the as...
Trafficking of immune cells is controlled by directed migration of relevant cells toward chemotactic signals. Actin cytoskeleton undergoes continuous remodeling and serves as machinery for cell migration. The mDia family of formins and the Wiskott-Aldrich syndrome protein (WASP)-Arp2/3 system are two major actin nucleating-polymerizing systems in mammalian cells, with the former producing long ...
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