A fractional-order vascular model representation for emulating arterial hemody-namics has been recently presented as an alternative to the well-known integer-order Windkessel. The uses a capacitor (FOC) describe complex and frequency-dependent compliance. This paper presents two-stage algorithm based on modulating functions finite-time simultaneous estimation of model’s input fractional differe...

Several methodologically independent measures of arterial stiffness derived from either the systolic or diastolic segments of the arterial pulse have been proposed. The exact nature of the large and small artery elasticity indices (C1 and C2, respectively) derived from diastolic pulse contour analysis remains largely unexplored, although C2 has controversially been termed to be "oscillatory" an...

A central problem in modeling blood flow and pressure in the larger systemic arteries is determining a physiologically based boundary condition so that the arterial tree can be truncated after a few generations. We have used a structured tree attached to the terminal branches of the truncated arterial tree in which the root impedance is estimated using a semianalytical approach based on a linea...

In an animal model, we examined the extratympanic electrocochleographic response to static pressure changes (middle-ear pressure and intracranial pressure [ICP]) with attention to the summating potential (SP), action potential (AP), and the SP/AP ratio. With a closed middle ear, raised or lowered middle-ear pressure and raised or lowered ICP resulted in congruent increases of the SP and the SP/...

We have searched to define the major arterial parameters that determine aortic systolic (Ps) and diastolic (Pd) pressure in the dog. Measured aortic flows were used as input to the 2-element windkessel model of the arterial system, with peripheral resistance calculated as mean pressure divided by mean flow and total arterial compliance calculated from the decay time in diastole. The windkessel ...

Computational fluid dynamics (CFD) study of hemodynamics in the aorta can provide a comprehensive analysis relevant cardiovascular diseases. One trending approach is to couple three-element Windkessel model with patient-specific CFD simulations form multi-scale that captures more realistic flow fields. However, case-specific parameters (e.g., Rc, Rp, and C) for must be tuned reflect conditions....

Modeling of the cardiovascular system is challenging, but it has the potential to further advance our understanding of normal and pathological conditions. Morphology and function are closely related. The arterial system provides steady blood flow to each organ and damps out wave fluctuations as a consequence of intermittent ventricular ejection. These actions can be approached separately in ter...