BACKGROUND Vero cell culture-derived whole-virus H5N1 vaccines have been extensively tested in clinical trials and consistently demonstrated to be safe and immunogenic; however, clinical efficacy is difficult to evaluate in the absence of wide-spread human disease. A lethal mouse model has been utilized which allows investigation of the protective efficacy of active vaccination or passive trans...

Deviations to other types’ equilibrium strategies. Let π(t̂, t) be the expected payoff of a bidder with type t̂ who makes the equilibrium bid of a bidder with type t. For t ≥ t∗∗, he wins the small item for free when his opponent has type tj > t, and the large object for B(t) otherwise, so π(t̂, t) = (1− t)u(t̂) + tU(t̂)− tE (max{r,X(s)} | s < t) = u(t̂) + tX(t̂)− t∗∗r − ∫ t t∗∗ X(s)ds ↓ ∂ ∂tπ(t̂, t) =...

in this study, the immunogenicity of a rabies vaccine that was used in one of the isfahan cattle farms is reported. this vaccine was produced by replication of the pasteur virus (pv) strain on bhk-21 monolayer cell culture. the virus suspension was inactivated by ß-propiolactone treatment and the harvested pool showed sterility and safety. thus, the obtained vaccine was tested on mice and a sat...

compared to other methods of vaccine production, (e.g. culture flask and bioreactor system), the roller culture method for producing rabies vaccine is simpler, and the equipment easier to install and maintain, and also in the event of contamination of one roller, the entire batch need not be discarded. this system provides a much larger surface area than the culture flask, and also ensures a mu...

Pertussis is a highly contagious respiratory illness caused by the bacterial pathogen Bordetella pertussis. Pertussis rates in the United States have escalated since the 1990s and reached a 50-year high of 48,000 cases in 2012. While this pertussis resurgence is not completely understood, we previously showed that the current acellular pertussis vaccines do not prevent colonization or transmiss...

BACKGROUND The objective of the study was to analyse the evolution of Bordetella pertussis population and the influence of herd immunity in different areas of the world where newborns and infants are highly vaccinated. METHODOLOGY The analysis was performed using DNA microarray on 15 isolates, PCR on 111 isolates as well as GS-FLX sequencing technology on 3 isolates and the B. pertussis refer...

A trial of the efficacy of a plain whole cell pertussis vaccine was conducted in Sweden. In this non-blinded trial 525 infants aged 2 months who were born on days with an even number received three doses of vaccine one month apart and 615 infants of the same age who were born on days with an odd number were enrolled as controls. During the 18 months of follow up there were 55 cases of pertussis...

Ovarian cancer is the fifth most leading cause of cancer related deaths in women in the US. Customized immunotherapeutic strategies may serve as an alternative method to control the recurrence or progression of ovarian cancer and to avoid severe adverse effects of chemotherapy. In this study, a microparticulate vaccine using whole cell lysate of a murine ovarian cancer cell line, ID8 was prepar...