Act iva t ion of the classical co mp le me n t p a t h w a y occurs when i m m u n e complexes in teract wi th the first componen t , C 1, to convert it from its inact ive precursor form to an act ive esterolyt ic enzyme, C I . 1 C I by p r o d u c i n g l i m i t e d proteolysis of C4 a n d C2 produces the classical p a t h w a y (23 convertase, C42 (1). T h e a l te rna t ive p a t h w a y is...

Stable isotope ratios of various organisms were analyzed to elucidate food web structure in the pelagic zone of Lake Baikal. The pelagic food web of Lake Baikal is simple and consists of five major ecological groups: phytoplankton (Aulacoseira baicalensis), mesozooplankton (Epischura baicalensis), macrozooplankton amphipod (Macrohectopus branickii), fish (Coregonus autumnalis migratorius and fo...

Accumulating preclinical data suggest that compounds that block the excitatory effect of glutamate on excitatory amino acid receptors may have neuroprotective effects and utility for the treatment of neurodegeneration after brain ischemia. In the present study, the in vitro and in vivo pharmacological properties of the novel glutamate antagonist SPD 502 [8-methyl-5(4-(N,N-dimethylsulfamoyl)phen...

Batrachotoxin (BTX), a steroidal alkaloid, and pyrethroid insecticides bind to distinct but allosterically coupled receptor sites on voltage-gated sodium channels and cause persistent channel activation. BTX presumably binds in the inner pore, whereas pyrethroids are predicted to bind at the lipid-exposed cavity formed by the short intracellular linker-helix IIS4-S5 and transmembrane helices II...

En virtud de que el estudio la diversidad genética del maíz (Zea mays L.) en una región dada es conveniente con fin diseñar procedimientos para su mejor aprovechamiento, y estudios entre razas se ha sugerido serie caracteres como apropiados, importante determinar si las variables propuestas evaluar material genético pueden modificarse al valorar poblaciones agroecológica determinada. Con este p...