In order to pose eeective queries to Web sites, some form of site data model must be implicitly or explicitly shared by users. Many approaches try to compensate for the lack of such a common model by considering the hypertextual structure of Web sites; unfortunately, this structure has usually little to do with data semantics. In this paper a diierent technique is proposed that allows for both ...

The Frizzled (Fz) receptors contain seven transmembrane helices and an amino-terminal cysteine-rich domain (CRD) that is sufficient and necessary for binding of the ligands, the Wnts. Recent genetic experiments have suggested, however, that the CRD is dispensable for signaling. We engineered fz CRD mutant transgenes and tested them for Wg signaling activity. None of the mutants was functional i...

The objective of the present work was to develop a quantitative risk assessment model in which the exposure and risk of acquiring listeriosis from consumption of packaged smoked or gravad salmon and rainbow trout were estimated. An Excel spreadsheet model was constructed in which variables were represented by distributions based on surveys of L. monocytogenes in these food products, and on demo...

Revision history Revision 0 (3 May 2006) First revision Revision 1 (10 June 2006) Incorporated comments from May 2006 CAP WG changed to SET/REPORT DEVICE IDENTIFIER commands instead of the Device Identification VPD page 83h. Revision 2 (7 September 2006) Incorporated comments from July 2006 CAP WG renamed to SET/REPORT IDENTIFYING INFORMATION to avoid overuse of “identifier”, increased the info...

The Wnt-Wingless (Wg) pathway regulates development through precisely controlled signaling. In this study, we show that intracellular trafficking regulates Wg signaling levels. In Drosophila melanogaster cells stimulated with Wg media, dynamin or Rab5 knockdown causes reduced Super8XTOPflash activity, suggesting that internalization and endosomal transport facilitate Wg signaling. In the wing, ...

Insect wing is a key evolutionary innovation for insect radiation, but its origins and intermediate forms are absent from the fossil record. To understand the ancestral state of the wing, expression of three key regulatory genes in insect wing development, wingless (wg), vestigial (vg), and apterous (ap) was studied in two basal insects, mayfly and bristletail. These basal insects develop dorsa...

The Drosophila signaling molecule Wingless (Wg) plays crucial roles in cell-cell communications during development. In the developing nervous system, a previous study has shown that Wg acts non-autonomously to specify the fate of a specific neuronal precursor, NB4-2 (Q. Chu-LaGraff and C. Q. Doe (1993) Science 261, 1594-1597). The lack of autocrine specification of NB4-2 in Wg-expressing cells ...

In this paper we discuss the possibility to represent synthetically semistructured information via a loose notion of schema: we say that data are semistructured when, although some structure is present, it is not as strict, regular, or complete as the one required by the traditional database management systems. Our proposal is based on WG-Log, a graph based language for the representation of WW...