OBJECTIVE: To describe the response of a medication-refractory, 16-year old male with severe Tourette syndrome (TS) and typical co-morbidities to bilateral deep brain stimulation (DBS) of the globus pallidus interna (GPi). BACKGROUND: Case reports suggest efficacy of DBS in treating severe TS. A medication-refractory, 16-year old male with severe Tourette syndrome (TS) and typical co-morbiditie...

To the Editors: At least a third of HIV-infected infants have slow progressing disease and even without HIV treatment have a 50% probability of surviving to adolescence. Hence, substantial numbers of adolescents, infected before interventions to prevent mother-to-child HIV transmission became available, are presenting to clinical services with undiagnosed HIV in sub-Saharan Africa. A high burde...

SYLL/SEC AND SEC/SYLL SCORES ARE NOT EQUIVALENT, EVEN IF THEY COME FROM THE SAME TEST The diagnosis of developmental dyslexia requires measures of reading ability to be at least two standard deviations (SD) below age mean, encompassing accuracy, speed, and comprehension (ICD10, WHO, 1992). Reading speed is typically measured in either seconds per syllable (sec/syll) or syllables per second (syl...

Introduction: 3D arterial spin labelling (ASL) perfusion methods provide a method of simultaneous sampling of the imaging volume, eliminating slice dependent variation in perfusion signal due to differences in acquisition delays that occurs in 2D multi-slice methods. Further, 3D methods are of particular benefit to background suppressed ASL [1] as the static signal is attenuated to an equal ext...

It has been suggested that bibliometric analysis of different document types may reveal new aspects of research performance. In medical research a number of study types play different roles in the research process and it has been shown, that the evidence-level of study types is associated with varying citation rates. This study focuses on clinical practice guidelines, which are supposed to gath...

Introduction Resting state low frequency temporal fluctuations as measured using blood oxygenation level-dependent (BOLD) weighted imaging has been hypothesized to reflect a measure of functional connectivity for the reference region of interest (ROI) [1-3]. The study of endogenous low frequency BOLD fluctuations (LFBF) is promising and has been shown to correlate with white matter pathway inte...

The gastric pathogen Helicobacter pylori is a major cause of acute chronic gastritis and the development of stomach and duodenal ulcers. Chronic infection furthermore pre-disposes to the development of gastric cancer. Crucial to H. pylori survival within the hostile environment of the digestive system are the adhesins SabA and BabA; these molecules belong to the same protein family and permit t...

Two methods were proposed recently to derive energy parameters from known native protein conformations and corresponding sets of decoys. One is based on nding, by means of a perceptron learning scheme, energy parameters such that the native conformations have lower energies than the decoys. The second method maximizes the di erence between the native energy and the average energy of the decoys,...

Two methods were proposed recently to derive energy parameters from known native protein conformations and corresponding sets of decoys. One is based on nding, by means of a perceptron learning scheme, energy parameters such that the native conformations have lower energies than the decoys. The second method maximizes the di erence between the native energy and the average energy of the decoys,...

Adherence of bacteria to biotic or abiotic surfaces is a prerequisite for host colonization and represents an important step in microbial pathogenicity. This attachment is facilitated by bacterial adhesins at the cell surface. Due to their size and often elaborate multi-domain architectures, these polypeptides represent challenging targets for detailed structural and functional characterization...