BACKGROUND The opioid antagonist naltrexone has shown promise to reduce weight gain during active treatment, but longer-term studies have not been conducted. The goal was to examine effects of naltrexone on weight gain over long-term follow-up in men and women who quit smoking. METHODS Weight was examined at baseline and 6- and 12-month follow-up in the two largest randomized, double-blind, p...

BACKGROUND Low molecular weight heparins (LMWH) have become increasingly important in anticoagulant therapy. Antitumor and antimetastatic activity of heparin and LMWH-s have also been reported. MATERIALS AND METHODS Fraxiparine, a new modified LMW-H, was tested for antimetastatic effect using 3LL-HH intravenous, B16 intra-foot pad and 3LL-HH intrasplenic models in C57 Bl/6 mice. The dose of F...

Bu çalışmada, TMK m. 677-678 hükümleri çerçevesinde miras payının devrine yönelik sözleşmeler konu unsuru bakımından incelenmektedir. 677 hükmünde, mirasın açılmasından sonra ilişkin devralanın başka bir mirasçı olup olmadığına göre farklı düzenlenmiş; 678 hükmünde ise önce yapılan sözleşmelerde bu tarz ayrım gözetilmemiştir. Çalışmanın amacı, kanun koyucunun sözleşmeleri düzenlerken gözettiği ...

BACKGROUND The protein equivalent of total nitrogen appearance (PNA) is assumed to be a reliable estimate of dietary protein intake in haemodialysis patients. Protein requirements are related to body size. In order to standardize PNA to individual differences in body size, PNA is normalized to various terms related to the patient's body weight. It is not clear which is the most appropriate meth...

OBJECTIVES This investigation evaluated the role of obesity in health status and behaviors for weight management and exercise among individuals with type 2 diabetes mellitus (T2DM) or cardiometabolic risk factors. METHODS Self-reported health status, exercise behaviors, and weight management were assessed in the SHIELD study for respondents with T2DM or high risk (HR) for diabetes (ie, ≥3 of ...

PURPOSE To assess the relationship between body mass index (BMI), subcutaneous and intra-abdominal fat, liver density, and histopathologic hepatic steatosis. MATERIALS AND METHODS In this retrospective study, 143 patients (male/female, 67/76; mean age, 50 years) underwent a non-targeted transjugular (n = 125) or percutaneous (n = 18) liver biopsy between 2006 and 2010. The biopsy indications ...

BACKGROUND Overweight and obesity are common in the Netherlands: in 2006 51% of adult men and 42% of adult women were overweight; 10% of men and 12% of women were obese. Patients with overweight or obesity in the Netherlands are often referred to dietitians in primary care for weight loss treatment. We followed a prospective observational cohort to study the effectiveness of this treatment and ...