Introduction Lymphoma is the most common cancer in HIV/AIDS patients. Chemotherapy regiments recommended for lymphomas HIV-negative patients are also used Little known about infections among with lymphoma undergoing chemotherapy.Methods This retrospective study investigated incidence, spectrum of and risk factors during chemotherapy 164 admitted to Shanghai Public Health Clinical Center from Ju...

■ CONTENTS Kinetic Capillary Electrophoresis 157 Applications 159 Aptamers 159 KCE for Quantitative Characterization of Aptamer-Target Binding 159 KCE-Based Aptamer Selection 160 Small Molecules 161 Cyclodextrins 162 Proteins 162 Others 164 Instrumentation and Methodology 164 Sample Preparation 164 Capillary Coatings 165 KCE-MS 165 Computational and Mathematical Approaches 166 Validation 167 Co...

Previously, human hepatitis B virus (HBV) mutant 164, which has a truncation at the C terminus of the HBV core antigen (HBcAg), was speculated to secrete immature genomes. For this study, we further characterized mutant 164 by different approaches. In addition to the 3.5-kb pregenomic RNA (pgRNA), the mutant preferentially encapsidated the 2.2-kb or shorter species of spliced RNA, which can be ...

PURPOSE c-Src has been shown to play a pivotal role in breast cancer progression, metastasis, and angiogenesis. In the clinic, however, the limited efficacy and high toxicity of existing c-Src inhibitors have tempered the enthusiasm for targeting c-Src. We developed a novel c-Src inhibitor (UM-164) that specifically binds the DFG-out inactive conformation of its target kinases. We hypothesized ...

BACKGROUND AND PURPOSE Transcranial color-coded duplex sonography (TCCD) is a diagnostic technique for evaluation of intracranial arteries in patients with acute stroke. Echo-enhancing contrast agents (EEAs) are necessary to visualize intracranial vessels in up to 30% of patients because of limited acoustic bone windows. In this study, we assessed the diagnostic efficacy of echo-enhanced TCCD (...

We assessed the effect of β-Glucan on macrophages by Griess reagent and viability by MTT assay and cytotoxicity. Assay of macrophages culture supernatants were carried out on WEHI-164 fibrosarcoma cell line as tumor necrosis factor-α bioassay were done. NO release was increased at the dose of 10 µg/ml (P = 0.001) of β-Glucan while the viability of macrophages in all concentrations was the same....