Yorkie (Yki), a transcription factor of the Fat and Hippo signaling pathways, is negatively regulated by the Warts kinase. Here, we use Phos-tag gels to characterize Warts-dependent phosphorylation of Yki in vivo, and show that Warts promotes phosphorylation of Yki at multiple sites. We also show that Warts inhibits Yki nuclear localization in vivo, and can promote binding of Yki to 14-3-3 prot...

BACKGROUND Genital warts are caused by human papillomavirus infection and represent one of the most common sexually transmitted diseases. Many infections are transient but the virus may recur, persist, or become latent. To date, there is no effective antiviral treatment to eliminate HPV infection and most therapies are aimed at the destruction of visible lesions. Potassium hydroxide is a strong...

Background: A safe, simple, effective method of treating warts is needed. Objectives: To evaluate 1) safety of candida antigen injections for the treatment of common warts, 2) patient satisfaction with the treatment. Methods: Chart review and telephone follow-up of 149 patients treated for common warts by intradermal and intralesional candida antigen injections. Results: 104 were reached by tel...

<p class="abstract"><strong>Background:</strong> Warts are one of the most common benign growths skin caused by human papilloma virus. No single treatment has proved to be completely effective and therapies for palmo-plantar periungual warts remain unsatisfactory. The present study was conducted evaluate therapeutic efficacy safety intralesional bleomycin injection in patients...

The mitotic apparatus plays a pivotal role in dividing cells to ensure each daughter cell receives a full set of chromosomes and complement of cytoplasm during mitosis. A human homologue of the Drosophila warts tumor suppressor, h-warts/LATS1, is an evolutionarily conserved serine/threonine kinase and a dynamic component of the mitotic apparatus. We have identified an interaction of h-warts/LAT...

OBJECTIVE To assess whether anogenital warts, present or past, are an indication for women to be referred for colposcopy. DESIGN A case control study comparing patients with and without a history of anogenital warts. SETTING A department of genitourinary medicine in West London. PATIENTS 468 patients examined by colposcopy between January 1985 and December 1987 of whom 147 (31%) had abnor...

Background: Human papillomavirus (HPV) is a large group of DNA viruses that cause skin and mucosal warts. Zinc is used in the treatment of skin diseases. Zinc has been used in the treatment of various skin and systemic diseases. Warts are benign proliferation of the skin and mucosa. The prevalence of skin warts is higher in children and its peak is in adolescence and then decreases with age. So...

Objectives To compare the therapeutic efficacy of intralesional mumps, measles, and rubella (MMR) vaccination, vitamin D3 (VitD3), bleomycin injection in patients with warts. Background With good outcomes, common warts have been treated immunotherapy using antigens or vaccinations. It might result resolution without any outward signs deterioration scarring boost host’s defenses against agent th...

Background: Warts are considered the foremost common infectious diseases affecting epidermal keratinocytes, causative agent is human papilloma virus (HPV). Diagnosis usually can be confirmed depending on both clinical features and family history. Although these viruses create no acute signs or symptoms, they induce slow growth of lesions that remain for a long period. Aim: This study aims to as...

OBJECTIVE To assess the efficacy and safety of topical zinc sulphate solution in the treatment of plane and common warts. METHODS This study consisted of a pilot and double blinded clinical trails. This was carried out in the Department of Dermatology and Venereology, Baghdad Teaching Hospital, Baghadad, Iraq during the period from December 2002 to October 2003. Ten patients with plane warts ...