Targeting of G-protein coupled receptors (GPCRs) like somatostatin-14 (SST-14) could have a potential interest in delivery of anti-cancer agents to tumor cells. Attachment of SST to different nano-carriers e.g. polymeric nanoparticles is limited due to the difficulty of interaction between SST itself and those nano-carriers. Furthermore, the instability problems associated with the final formul...

OBJECTIVE Somatostatin (SST) is secreted by islet delta-cells and by extraislet neuroendocrine cells. SST receptors have been identified on alpha- and beta-cells, and exogenous SST inhibits insulin and glucagon secretion, consistent with a role for SST in regulating alpha- and beta-cell function. However, the specific intraislet function of delta-cell SST remains uncertain. We have used Sst(-/-...

The purpose of the present work is to demonstrate that a solar cycle response exists in surface temperature using the longest global dataset available, which is in the form of 1854–2007 sea surface temperature (SST), with an emphasis on methods and procedures, data quality, and statistical tests and the removal of deterministic signals, such as volcano aerosol forcing and greenhouse gas warming...

Neuronal activity regulates multiple aspects of the morphological and functional development of neural circuits. One mechanism by which it achieves this is through regulation of gene expression. In a screen for activity-induced genes, we identified somatostatin (SST), a neuropeptide secreted by the SST subtype of interneurons. Using real time quantitative PCR and ELISA, we showed that persisten...

Soshiho-tang (SST; sho-saiko-to in Japanese; xiaochaihu-tang in Chinese) has generally been used to improve liver fibrosis- and cirrhosis-related symptoms in traditional Korean medicine. Although many studies have investigated the pharmacological properties of SST, its antiobesity effect has not been elucidated. Thus, our present study was carried out to evaluate the antiobesity effect of SST u...

Somatostatin mediates its diverse physiological effects through a family of five G-protein-coupled receptors (sst(1)-sst(5)); however, knowledge about the distribution of individual somatostatin receptor proteins in mammalian brain is incomplete. In the present study, we have examined the regional and subcellular distribution of the somatostatin receptor sst(4) in the rat CNS by raising anti-pe...

OBJECTIVE To test the hypothesis that a reduction of somatostatin (SST) in the retina exists in patients without clinically detectable diabetic retinopathy and that it is associated with retinal neurodegeneration. RESEARCH DESIGN AND METHODS Human diabetic postmortem eyes (n = 10) without clinically detectable retinopathy were compared with eyes (n = 10) from nondiabetic donors. SST mRNA (RT-...

In somatostatinoma, a rare malignant somatostatin (SST)-secreting neoplasia, tumour regression is rarely observed, implying the need for novel antiproliferative strategies. Here, we characterized a long-term culture (SST-secreting cancer (SS-C cells)) established from a human somatostatinoma. High concentrations of SST and chromogranin A were released by SS-C cells and SST release was stimulate...

The Tropical Rainfall Mapping Mission Microwave Imager (TMI) instrument Sea Surface Temperature (SST) product (v1.0) is compared with in situ observations obtained in the Atlantic Ocean. The TMI SST has a mean warm bias of 0.25K¡0.7K when compared to in situ SST at a depth of 7m. When TMI SST are compared to in situ skin SST measurements, the bias is 0.6K¡0.5K. A limited global comparison betwe...

The spatial distribution of sperm within the sperm storage tubules (SST) found in the uterovaginal junction (UVJ) of the turkey is not known. In this study, we inseminated sperm stained with a fluorescent dye (Hoechst 33342) to determine their distribution in SST in the ventral, dorsal, and lateral regions of the proximal, middle, and distal regions of the UVJ. There was no preferential filling...