Abnormalities in the brain generally manifest on MRI as changes in shape (morphometry) or changes in the nature of the tissue (signal intensity). Voxel-based statistical analysis approaches are able to objectively detect such changes throughout the brain. For example, Voxel Based Morphometry (VBM) [2] and Voxel Based T2relaxometry (VBR) [3] can detect subtle changes in tissue volume and T2 sign...
