We prove that for all 1 ≤ p ≤ ∞, p 6= 2, the Lp spaces associated to two von Neumann algebrasM, N are isometrically isomorphic if and only if M and N are Jordan *-isomorphic. This follows from a noncommutative Lp Banach-Stone theorem: a specific decomposition for surjective isometries of noncommutative Lp spaces.