Background: Vitiligo is a common depigmentary disorder characterized by white patches of the skin, hair and mucous membranes due to selective destruction of melanocytes. Objective: The objective of this study was to analyze the clinical characteristics, coexisting diseases, presence of autoantibodies and autoimmune polyglandular syndrome (APS) in Estonian adult vitiligo patients. Methods:Adult ...

Background: Atopy is according to some authors frequently accompanying vitiligo. We investigated the problem in a series of patients. Materials and Methods: 64 vitiligo patients and 58 controls of a similar age and sex distribution participated in the study. Detailed histories concerning the atopic diseases and total serum IgE levels were obtained. These findings were assessed considering also ...

Background: Vitiligo is characterized by selective destruction of melanocytes. Transforming growth factor beta 1 (TGFβ 1) is the main product of regulatory T cells (Tregs) which are deficient in vitiligo. Thus, lower levels of serum TGFβ 1 are expected in vitiligo. However, TGFβ 1 is a keratinocytederived cytokine with inhibitory effect on melanocyte activity. Thus it may be expected to be high...

© 2018 Indian Dermatology Online Journal | Published by Wolters Kluwer Medknow Sir, Vitiligo is an idiopathic depigmentory skin disorder.[1] One of the first clues for the involvement of cellular immunity in the pathogenesis of vitiligo was the discovery of T‐cell infiltration in the margins of vitiligo skin lesions.[2] Furthermore, increased production of interleukin (IL)‐6, IL‐8 and tumor nec...

Vitiligo is the most common depigmentation disorder, affecting 0.5% of the population worldwide. It has a major negative impact on the quality of life of patients [1,2]. Vitiligo that begins in childhood can be associated with significant psychological trauma that may have a long-lasting effect on personal self esteem [3]. However, vitiligo is still largely perceived as a cosmetic disorder and ...

The acquired depigmenting disorder of vitiligo affects an estimated 1% of the world population and constitutes one of the commonest dermatoses. Although essentially asymptomatic, the psychosocial impact of vitiligo can be severe. The cause of vitiligo remains enigmatic, hampering efforts at successful therapy. The underlying pathogenesis of the pigment loss has, however, been clarified to some ...

One thousand consecutive new male patients attending a clinic for sexually transmitted diseases were screened with Wood's light for the presence of genital vitiligo. Two patients had idiopathic vitiligo and one probable occupational vitiligo.

BACKGROUND Vitiligo and atopic dermatitis (AD) are common dermatological disorders which may cause significant psychological and social distress leading to impaired quality of life (QoL) in patients. OBJECTIVE We evaluated the degree of psychological stress and impairment of QoL in vitiligo patients as compared with AD patients and normal controls (NCs). METHODS A total of 60 patients from ...

Genetic polymorphisms in TNFB are involved in the regulation of its expression and are found to be associated with various autoimmune diseases. The aim of the present study was to determine whether TNFB +252A/G (rs909253) and exon 3 C/A (rs1041981) polymorphisms are associated with vitiligo susceptibility, and expression of TNFB and ICAM1 affects the disease onset and progression. We have earli...

INTRODUCTION Vitiligo is an acquired, idiopathic disorder characterized by circumscribed depigmented macules and patches, which affects approximately 0.1-2% of the general population worldwide. Zinc is an essential trace element that is necessary for growth and development at all stages of life. Some studies have reported an association between serum zinc levels and vitiligo. AIM To measure t...