Intestinal absorption of [3H]phylloquinone was investigated in the unanesthetized rat by the use of a technique of recirculating perfused isolated intestinal segments. Apparent saturation kinetics were found as the concentration of the vitamin in the perfusate was increased in a stepwise fashion from 15 nM to 300 muM. Alkalinization of the perfusate or the addition of 2.5 mM linoleic acid to th...

Vitamin K comprises a group of substances, which are widespread in nature and are an essential co-factor in humans in the synthesis of several proteins that play a role in haemostasis and others that may be important in calcium homeostasis. The K vitamins all contain the 2-methyl-1,4-naphthoquinone (menadione) moiety, and the various naturally occurring forms differ in the alkyl substituent at ...

Fat-soluble vitamin regulation is of particular significance in cystic fibrosis. A vitamin is an organic compound required as a nutrient in tiny amounts by an organism. In the present study, we had developed a simple method to estimate the fat soluble vitamin by Spectrophotometer. The vitamin A, D, E and K were estimated by spectrophotometer at 325 nm, 264 nm, 525 nm and 635 nm respectively. Af...

We introduce the notion of a K3 spectrum in analogy with that of an elliptic spectrum and show that there are “enough” K3 spectra in the sense that for all K3 surfaces X in a suitable moduli stack of K3 surfaces there is a K3 spectrum whose underlying ring is isomorphic to the local ring of the moduli stack in X with respect to the etale topology, and similarly for the ring of formal functions ...

Let k3(n) denote the minimal cardinality of a ternary code of length n and covering radius one. In this paper we show k3(7) ≥ 156 and k3(8) ≥ 402 improving on the best previously known bounds k3(7) ≥ 153 and k3(8) ≥ 398. The proofs are founded on a recent technique of the author for dealing with systems of linear inequalities satisfied by the number of elements of a covering code, that lie in k...

A study on the relation between the smooth structure of a symplectic homotopy K3 surface and its symplectic symmetries is initiated. A measurement of exoticness of a symplectic homotopy K3 surface is introduced, and the influence of an effective action of a K3 group via symplectic symmetries is investigated. It is shown that an effective action by various maximal symplectic K3 groups forces the...

Mesenchymal stem cells (MSCs) transplantation has been used for therapeutic applications in various diseases. Here we report MSCs can malignantly transform in vivo. The novel neoplasm was found on the tail of female rat after injection with male rat bone marrow-derived MSCs (rBM-MSCs) and the new tumor cell line, K3, was isolated from the neoplasm. The K3 cells expressed surface antigens and pl...

We previously found that vitamin K3 (menadione, 2-methyl-1,4-naphthoquinone) inhibits the activity of human mitochondrial DNA polymerase γ (pol γ). In this study, we focused on plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone), and chemically synthesized novel plumbagins conjugated with C2:0 to C22:6 fatty acids (5-O-acyl plumbagins). These chemically modified plumbagins enhanced mammalian pol ...

S. Bauer and M. Furuta defined a stable cohomotopy refinement of the Seiberg-Witten invariants. In this paper, we prove a vanishing theorem of Bauer-Furuta invariants for 4-manifolds with smooth Z2-actions. As an application, we give a constraint on smooth Z2-actions on homotopy K3#K3, and construct a nonsmoothable locally linear Z2-action on K3#K3. We also construct a nonsmoothable locally lin...

The tumor growth-inhibiting and chemo-potentiating effects of vitamin C and K(3)combinations have been demonstrated both in vitro and in vivo. The purpose of this study was to investigate the influence of orally administered vitamin C and K(3) on the metastasis of mouse liver tumor (T.L.T.) cells implanted in C3H mice. Adult male C3H mice were given water containing vitamin C and K3 (15 g/0.15 ...