We report a case of Muir-Torre syndrome (MTS) with a very rare combination of cancers, involving bilateral eyelid cancers and breast cancer. A 71-year-old female with a history of breast cancer from 18 years prior presented with bilateral eyelid tumors. One of her siblings had lung cancer, and another had pancreatic cancer. She underwent excisional biopsy of the eyelid tumors and histopathology...

Basal cell carcinomas, the most common human tumors, generally appear sporadically and in small numbers. Rarely, they may appear in great numbers and at an earlier age as a manifestation of the basal cell nevus syndrome, an autosomal dominant inherited disorder. Drawing on the retinoblastoma paradigm, we have begun a search for tumor suppressor genes important in the development of basal cell c...

pleuropulmonary blastoma (ppb) is a rare, malignant intrathoracic tumor that occurs mostly in children before 5 years old. it consists about 15% of all primary pediatric pulmonary tumors and shows various mesenchymal components. its presentations are nonspecific and common symptoms include fever, cough, chest pain, respiratory distress, and pulmonary infection. ppb should be considered in the d...

using complement fixation technique, serial serum samples from 15 patients undergoing surgical removal of malignant tumors were assayed for the presence of tumors antibodies against the cellular fractions of both normal and carcinomatous tissue. antibody responses against tumor associated antigens were detected in four cases. in all cases antibody activity was directed only against the supernat...

background and aims. head and neck tumors are the most common complaints of people referring to different medical sections, especially in children. the aim of this study was to evaluate the prevalence of these tumors in children less than 12 years of age to provide a better perspective for future studies. materials and methods. all the files in department of pathology at tabriz pediatric hospit...

background: understanding the differences in genetics of malignancies is crucial for therapeutic decisions. this systematic review was conducted to evaluate the current evidence on genetics of bone tumors in the context of pediatric cancer. material and methods: we performed a systematic review of the literature published on genetics of pediatrics bone tumors, using pubmed, google scholar, scie...

rejection of the tumors in all 12 animals that was completed within 7 days. These animals exhibited resistance to s.c. reinjection of large doses of cells of the same tumor line initially used, but died with growing tumors and métastases when tumor cells of an antigenically different syngeneic line were injected. Nine of the 12 animals treated by surgical excision of the tumor nodule at Day 14...

Background: We investigated the mutational landscape of skin tumors in patients with Muir-Torre Syndrome (MTS) a hereditary autosomal dominant mismatch repair disorder increased cancer susceptibility, and examined mutations other than DNA (MMR) genes. Methods: This retrospective single-center case series included seven diagnosis precise medical history family history. Mutational analysis tumor ...

Since Ewing’s first report of a previously unrecognized tumor of bone derived from endothelial elements (1)’ there have been numerous reports of tumors which have conformed with his endothelial myeloma, and others which have sought to deny the existence of such a tumor. Among these was an article by the present writer (2) agreeing almost entirely with Ewing’s conclusions. Kolodny (3) believed t...

metallothionein (mt) manifests varying expression levels in carcinomas, and they may be considered as valuable cell cancerization biomarkers for diagnosis of patients with cancers. a meta-analysis was conducted to evaluate comprehensively the mt expression difference in various benign tumors and malignant tumors, which compared the high with low mt expression levels in patients of the available...