Stereoregular vinyl polymers, poly(2-vinyl pyridine)s (P2VPs), were synthesized to examine the tacticity effect on the induced circular dichroism (ICD) via association with chiral acids. The ICD was found to be strongly dependent on the isotacticity of the P2VPs and the acidity of chiral acid in addition to its bulkiness.

3.3. Proteasome Inhibitors 1518 3.3.1. Peptide Aldehydes 1519 3.3.2. Boronic Acid Inhibitors 1519 3.3.3. -Lactones 1519 3.3.4. Epoxyketones 1519 3.3.5. Vinyl Sulfones 1519 3.3.6. Vinyl Ketones 1520 3.3.7. Cyclic Peptides 1520 3.3.8. Targeting of Cancer Cells 1520 4. Regulatory Particles Proteasome Activators 1520 4.1. 19S Regulatory Particle/PA70

The zinc-mediated regioselective addition reactions of diethyl bromomalonate and aromatic and aliphatic alkynes were investigated for the synthesis of vinyl malonates. When the vinyl organo-zinc intermediates were reacted with acid chlorides 2H-pyran-2-ones were obtained while the application of oxalyl chloride and an amine led to tetracarbonyl derivatives in a one-pot multi-step reaction seque...

The synthesis of graft copolymer (partially carboxymethylated guar gum-g-N-vinyl-2-pyrrolidone) is carried out in nitrogen atmosphere using potassium peroxymonosulphate and glycolic acid as redox system. The effect of reaction variables including the concentration of N-vinyl-2-pyrrolidone (8×10−2 −2 −3 −3 −3 −3 vailable online 28 October 2010

BACKGROUND The proteasome is a multicatalytic protease complex responsible for most cytosolic protein breakdown. The complex has several distinct proteolytic activities that are defined by the preference of each for the carboxyterminal (P1) amino acid residue. Although mutational studies in yeast have begun to define substrate specificities of individual catalytically active beta subunits, litt...

Terminal deoxynucleotidyl transferase (TdT) was purchased from Fermentas Inc. (Vilnius, Lithuania). 2,2'-amino-di(2-ethyl-benzothiazoline sulphonic acid-6) ammonium salt (ABTS2-), deoxyadenosine triphosphate (dATP), deoxythymidine triphosphate (dTTP), deoxyguanosine triphosphate (dGTP), the oligonucleotide, SYBR Green II and 2-(4-morpholino) ethanesulfonic acid (MES) were obtained from Sangon (...

The chemical nature of the important new chromogen ABTS [2,2'-azino-di-(3-ethyl-benzthiazoline-6-sulphonic acid)] is described together with an account of the redox and spectroscopic properties of the system ABTS--H2O2--peroxidase. Keq. is calculated and a study of the steady-state kinetics over a whole range of substrate concentrations is reported. By using novel methods of kinetic analysis, a...