Local anesthetics (LAs) are known to bind Na+ channels in the closed, open, and inactivated states and reach their binding sites via extracellular and intracellular access pathways. Despite intensive studies, no atomic-scale theory is available to explain the diverse experimental data on the LA actions. Here we attempt to contribute to this theory by simulating access and binding of LAs in the ...

the present paper investigates turbulent mixed convection - radiation flow between two vertical parallel plates kept at different temperatures with variable thermophysical properties. the reynolds number, based on channel half-width and friction velocity and the grashof number, based on channel width and wall temperature difference, were assumed to be 150 and 1.6×106, respectively. numerical si...

Organic electrochemical transistors (OECTs) belong to the class of electrolyte gated organic (EGOTs) that offer a smooth interface with biology in combination high transconductance values typically few mS. Fabrication-wise, though, most up-to-date reported devices are limited two dimensional structures, where transistor channel is patterned on same plane as source and drain electrodes. Here, me...

Forced convective condensation in vertical channel is investigated numerically. The condensation boundary layers that occur due to temperature difference between the walls and saturation temperature of steam is simulated by the volume of fluid (VOF) method. The effect of variations in the hydraulic diameter, steam velocity, Re number and temperature difference between the wall and saturation te...