background :chronic obstructive pulmonary disease (copd) is a third leading cause of death.   methods : in this case control study, we prepared 5 cc bloods from the antecubital vein of 100 copd patients and 40 healthy individuals as control group. vascular endothelial growth factor (vegf) expression protein level was measured by elisa in both groups.   results : we found that concentration of v...

Objective(s): Herbal medicines are promising cancer preventive candidates. It has been shown that Punica granatum L. could inhibit angiogenesis and tumor invasion. In this study, we investigated whether the anti-angiogenic effect of pomegranate peel extract (PPE) is partly attributable to Peroxisome proliferator-activated receptors (PPARs) activation in the Human Umbilical Vein Endothelial Cell...

background and objectives: angiogenesis is essential for growth and metastasis of solid malignancies. tumor vessel count and expression of vascular endothelial growth factor (vegf), a potent angiogenic factor, have been associated with prognosis. this study was designed to assess vessels density by using cd31 and cd105 (endoglin) and their correlation with expression of vegf and proliferative i...

background: the effects of the vascular endothelial growth factor (vegf) gene ?2578c/a polymorphism on colorectal cancer (crc) risk have been investigated in some studies; however, the results of these studies were conflicting and ambiguous. therefore, we aimed to do a meta-analysis to investigate the association of vegf ?2578c/a polymorphisms with crc risk from all eligible case-control studie...

objective(s):although previous studies have confirmed the beneficial effects of human umbilical cord matrix stem cell (hucm) transplantation post myocardial infarction (mi), but this stem cell resource has no potential to induce angiogenesis. in order to achieve the process of angiogenesis and cardiomyocyte regeneration, two required factors for cardiac repair agents were examined namely; hucm ...

Vascular endothelial growth factor (VEGF) is a secreted heparin-binding mitogen; its growth-promoting activity is limited to vascular endothelial cells in vitro and VEGF also stimulates angiogenesis in vivo. To identify target cells for VEGF and investigate the potential physiological role of this factor, iodinated recombinant human VEGF (125I-rhVEGF) was used for in vitro ligand autoradiograph...

Vascular endothelial growth factor (VEGF)/vascular permeability factor is the prototype for a growing family of dimeric growth factors, which exert their effects on vascular and lymphatic endothelial cells, as well as on a wide range of other cell types. Gene targeting shows that most, if not all, of the factors and receptors in this family serve critical functions during vascular development o...

Background: Endometriosis is the presence of endometrium- like tissue in sites outside the uterine cavity, primarily on the pelvic peritoneum and ovaries. Ectopic endometrium for replacement and growth require to blood supply. Vascular endothelial growth factor (VEGF) is one of the most important intermediate of locality angiogenesis that product by monocytes and macrophages. This study evaluat...

Objective(s): It has been demonstrated that hydrogen sulfide plays a vital role in physiological and pathological processes such as regulating inflammation, oxidative stress, and vessel relaxation. The aim of the study was to explore the effect of hydrogen sulfide on angiogenesis in the ischemic adductor muscles of type 2 diabetic db/db mice and ischemic diabetic wound...