We analyse the structure of the algebraic manifolds Y of dimension 3 with H(Y,ΩjY ) = 0 for all j ≥ 0, i > 0 and h 0(Y,OY ) > 1, by showing the deformation invariant of some open surfaces. Secondly, we show when a smooth threefold with nonconstant regular functions satisfies the vanishing Hodge cohomology. As an application of these theorems, we give the first example of non-affine, non-product...