The effect of tamoxifen (TAM) on human endometrii carci noma was investigated in nude mice bearing an estrogen recep tor-positive or estrogen receptor-negative tumor. The receptornegative tumor grew rapidly, and the rates of tumor growth of 17/3-estradiol or TAM-treated animals were identical to the rate of controls. The estradici receptor and progesterone receptor (PR) concentrations in the tu...

Purpose – Many banks consider mobile-based technologies have improved the banking services through introduction of new banking facilities. One of the latest facilities developed in this area is the “mobile credit card.” The purpose of this study is to examine the factors that determine intention to use mobile credit card among Malaysia bank customers, as their new way in conducting payment tran...

In isolation, chemical reaction networks and tile-based selfassembly are well-studied models of chemical computation. Previously, we introduced the chemical reaction network-controlled tile assembly model (CRN-TAM), in which a stochastic chemical reaction network can act as a non-local control and signalling system for tile-based assembly, and showed that the CRN-TAM can perform several tasks r...

PURPOSE The antiestrogen tamoxifen (Tam) has been used as therapy against estrogen receptor (ER)-positive breast cancer for decades. Most tumors respond initially, but resistance frequently develops. The ER exists in a multiprotein complex containing the molecular chaperone heat shock protein (Hsp) 90, which is known to regulate the stability and activity of this receptor. Therefore, we investi...

A key objective of information technology (IT) research is to assess the value of technology for users and to understand the factors that ascertain this value in order to better deploy IT resources. A variety of new models are developed to understand the users’ IT behavior; it seems reasonable to examine if the existing models of users’ behavior will still apply. This paper uses structural equa...

E-Commerce’s virtuality poses questions concerning trust between buyer and seller. Web 2.0 formats have provided new complications for these questions. Companies are creating more social networking sites, experimenting with ways to use such networks for marketing purposes. This paper explores the issue of trust in social networking site transactions vs. those at more established e-commerce site...

The triphenylethylene antiestrogen tamoxifen (TAM) is believed to exert its antitumor effect via the estrogen receptor (ER). To test this hypothesis and to differentiate between ER-mediated and general cytotoxic effects of TAM, the growth-inhibitory effects of TAM and its in vivo metabolite 4-hydroxytamoxifen (OH-TAM) have been studied in five continuous human cancer cell lines, MCF7 and T47D (...

Tamoxifen (tam), an anti-breast cancer agent, is metabolized into tam-N-oxide by the hepatic flavin-containing monooxygenase and into N-desmethyl- and 4-hydroxy-tam by cytochrome P-450s (CYPs). Additionally, tam is metabolically activated by hepatic CYP3A, forming a reactive intermediate that binds covalently to proteins. Tam and 4-hydroxyandrostenedione (4-OH-A) are currently used to treat bre...

The presence of tumor-associated macrophages (TAMs) is significantly associated with poor prognosis of tumors. Currently, magnetic resonance imaging- (MRI-) based TAM imaging methods that use nanoparticles such as superparamagnetic iron oxide and perfluorocarbon nanoemulsions are available for quantitative monitoring of TAM burden in tumors. However, whether MRI-based measurements of TAMs can b...