bread-making quality in hexaploeid wheat is a complex trait for breeding programs. high molecular weight glutenin subunits (hmw-gs) have an important effect on dough stability and elasticity. the glu-1 loci that are encoded these subunits are located on the long arms of group-1 homologues chromosomes of the a, b and d genomes. in this work we used pcr-based dna markers to distinguish wheat brea...

In the last three decades, genre of research article, among other genres of academic writings, hasreceived the greatest attention. This attention is due to the vital role that research article plays inthe legitimating of claims and disciplines. Johns and Swales (2002) relate this attention to theintensive review process that research article goes through before getting “valorized and ratifiedby...

3545 Background: Consensus molecular subtypes (CMSs) can guide precision treatment of colorectal cancer (CRC). Currently available assays identify CMS1 and CMS4 cases well, while a dedicated test to distinguish CMS2 3 is lacking. This study aimed panel methylation markers between in patients with CRC. Methods: Fresh-frozen tumor tissue 239 stage I-III CRC was included. CMS classification perfor...

Practical estimation procedures for local linear estimation of an unrestricted failure rate when more information is available than just time are developed. This extra information could be a covariate and this covariate could be a time series. Time dependent covariates are sometimes called markers, and failure rates are sometimes called hazards, intensities or mortalities. It is shown through s...

Virtually all pharmaceutically-relevant biological mechanisms can be monitored quantitatively using specific protein markers in samples of serum, urine, or tissue. The value of effective biological markers is substantial, allowing carly dctcction and classification of toxicities, ranking of potential lead compounds, acceleration of clinical trials. and stratification of patients into the most r...

Molecular markers for renal cell carcinoma could guide early detection of localized disease in defined populations at high risk for the disease or early disease recurrence after nephrectomy for renal cell carcinoma. In addition, sensitive and specific markers may provide surrogate end points for clinical trials of treatment and/or disease prevention. Powerful techniques of genomic and proteomic...

The identification of informative in silico polymorphic genomic and genic microsatellite markers by comparing the genome and transcriptome sequences of crop genotypes is a rapid, cost-effective and non-laborious approach for large-scale marker validation and genotyping applications, including construction of high-density genetic maps. We designed 1494 markers, including 1016 genomic and 478 tra...

PURPOSE This study was designed to evaluate molecular markers for the detection of micrometastasis in esophageal adenocarcinoma, define algorithms to distinguish positive from benign lymph nodes and to validate these findings in an independent tissue set and in patients with p(N0) esophageal adenocarcinoma. EXPERIMENTAL DESIGN Potential markers were identified through literature and database ...

BACKGROUND Recent biotechnological developments have resulted in increasing interest in immunology biomarkers. These biomarkers have potential clinical utility in the near future as predictors of treatment response. Hence, clinical validation of these predictive markers is critical. FINDINGS The process of clinically validating a predictive biomarker is reviewed. Validation of a predictive bi...

AIM To screen novel markers for hepatocellular carcinoma (HCC) by a combination of expression profile, interaction network analysis and clinical validation. METHODS HCC significant molecules which are differentially expressed or had genetic variations in HCC tissues were obtained from five existing HCC related databases (OncoDB.HCC, HCC.net, dbHCCvar, EHCO and Liverome). Then, the protein-pro...