Although GABA neurotransmission has been suggested as a mechanism for Valeriana officinalis effects, CNS depression can also be evoked by inhibition of ionotropic (iGluR) and metabotropic glutamate receptors (mGluR). In this study, we examined if aqueous valerian extract interacted with glutamatergic receptors. Freshly prepared aqueous valerian extract was incubated with rat cortical synaptic m...

Extracts of Hypericum, Passiflora and Valeriana are used for the treatment of mild depression and anxiety. We were interested whether a combination of Hypericum and Passiflora exerts comparable effects to Hypericum alone. We used two well-established models for investigating extracts for their anti-depressant activity, namely the effects on synaptic uptake of serotonin and the forced-swimming-t...

Plant remedies, despite their innocuity reputation, are implicated in adverse events. The present review focuses on 30 popular herbs which are associated with severe and sometimes fatal hepatotoxicity: Actaea racemosa, Aloe barbadensis, Atractylis gummifera, Callilepsis laureola, Camellia sinensis, Centella asiatica, Chelidonium majus, Ephedra sinica, Garcinia cambogia, Hypericum perforatum, La...

Neotropical forests have many plant species of great value, be it nutritional, ornamental and, mainly, medicinal. The substances present in these are the most varied and families very relevant this regard. family Solanaceae comprises whose secondary metabolites, including alkaloids, make them an interesting pharmacological target. However, large number their often, which often morphologically s...

objective: the present study was undertaken to evaluate the possible analgesic, neuropharmacological, anti-diarrheal, and cytotoxic activities of the ethanol extract of leaves of solanum sisymbriifolium lam. (family: solanaceae). materials and methods: the analgesic activity was measured by acetic acid-induced writhing inhibition test. the neuropharmacological activities were evaluated using ho...