The c-Abl tyrosine kinase is activated by some forms of DNA damage, including ionizing radiation, but not UV radiation. The functions of this activation in the damage response pathways remain obscure. To identify potential targets of c-Abl kinase, we utilized the yeast two-hybrid system to screen a murine cDNA library. One c-Abl binding protein of particular interest was the large subunit (DDB1...

The oncoprotein c-Myc is essential for cell growth and proliferation while its deregulated overexpression is associated with most human cancers. Thus tightly regulated levels and activity of c-Myc are critical for maintaining normal cell homeostasis. c-Myc is down-regulated in response to several types of stress, including UV-induced DNA damage. Yet, mechanism underlying UV-induced c-Myc reduct...

In this study, morphological and physiological effects of the stress with the UV-C rays on the industrial Atlanta type beans (Phaseolus vulgaris L. Cv, Atlanta) were analyzed. The plants were raised in an automated green house with the ecological conditions. The plants were grown in the green house with UV-C lamb (250) for 6, 8, 10, 12 and 14 days. After which their root lengths and seeding hei...

Plants use sunlight for photosynthesis and, as a consequence, are exposed to the ultraviolet (UV) radiation that is present in sunlight. UV radiation is generally divided into three classes: UV-C, UV-6, and UV-A. The UV-C region of the UV spectrum includes wavelengths below 280 nm; these highly energetic wavelengths are effectively absorbed by ozone in the stratosphere and, thus, are not presen...

Previous pharmacological results confirmed that haem oxygenase-1 (HO-1) is involved in protection of cells against ultraviolet (UV)-induced oxidative damage in soybean [Glycine max (L.) Merr.] seedlings, but there remains a lack of genetic evidence. In this study, the link between Arabidopsis thaliana HO-1 (HY1) and UV-C tolerance was investigated at the genetic and molecular levels. The maximu...

UV-C radiation is known to induce metabolic modifications in plants, particularly to secondary metabolite biosynthesis. To assess these modifications from a global and untargeted perspective, the effects of the UV-C radiation of the leaves of three different model plant species, Cissus antarctica Vent. (Vitaceae), Vitis vinifera L. (Vitaceae) and Cannabis sativa L. (Cannabaceae), were evaluated...

PURPOSE The cornea is sensitive to ultraviolet B (UV-B) radiation-induced oxidative stress and inflammation. Its clinical manifestations are photokeratitis and climatic droplet keratopathy. Urocanic acid (UCA) is a major endogenous UV-absorbing chromophore in the epidermis and it is also an efficacious immunosuppressant. We have previously shown that cis-UCA can suppress UV-B-induced interleuki...

Background: Despite the great health significance of Legionella, there is only little information on their UV sensitivity. Besides Legionella pneumophila only L. longbeachae has been investigated so far. Methods: In this study L. rubrilucens has been spread on buffered charcoal yeast extract agar and irradiated with the 254 nm UV-C emission of a mercury vapor lamp. The disinfection success is m...

Complex changes to UV radiation at the Earth's surface are occurring concurrently with ocean warming. Despite few empirical tests, jellyfish are hypothesised to be increasing in some parts of the world because they are robust to environmental stressors. Here we examine the effects of UV-B and ocean warming projections on zooxanthellate jellyfish polyps. We exposed Cassiopea sp. polyps to three ...

Results:  UV-C Technology effectively reduces environmental contamination and should be considered when environmental transmission is significant.  The Optimum UV TM device achieved an overall 3.56-log10 reduction for MRSA in 5 minutes and an overall 2.78-log10 reduction for C. difficile spores in 10 minutes in typical patient rooms (not treated with UV reflective wall coating).  When the pa...