Improving the profile of a molecule for the drug-discovery process requires the simultaneous optimization of numerous, often competing objectives. Traditionally, standard chemoinformatics methods ignored this problem and focused on the sequential optimization of each single biological or chemical property (ie, a single objective). This approach, known as single-objective optimization (SOOP), st...

background : cardiac arrest is a condition in which the heart is completely stopped and is not pumping any blood. although most cardiac arrest cases are reported from homes or hospitals, about 20% occur in public areas. therefore, these areas need to be investigated in terms of cardiac arrest incidence so that places of high incidence can be identi-fied and cardiac rehabilitation defibrillators...

Blade element momentum methods are widely used for initial aerodynamic analysis of propellers and wind turbines. A wide variety correction exist, but common to all variations, a pair residuals converged ensure compatibility between the two theories. This paper shows how rearrange sequence calculations reducing single residual. yields significant advantage that convergence can be guaranteed mach...