BACKGROUND Urocortin is a novel cardioprotective agent that can protect cardiac myocytes from the damaging effects of ischemia/reperfusion both in culture and in the intact heart and is effective when given at reperfusion. METHODS AND RESULTS We have analyzed global changes in gene expression in cardiac myocytes after urocortin treatment using gene chip technology. We report that urocortin sp...

Using confocal laser scanning microscopy we investigated the Ca(2+) distribution in single corticotropin releasing factor- and urocortin-stimulated human skin cells. The models tested included melanoma cells, neonatal melanocytes and keratinocytes, and immortalized HaCaT keratinocytes. The changes in intracellular Ca(2+) signal intensities observed after stimulation of different cell types with...

s/Idézhető absztraktok: 1. Jancsó G., Borsiczky B., Szántó Z., Cserepes B., Karosi Z., Solymos A., Kiss K., Szeberényi J., Rőth E. :NFkB és AP-1 transzkripciós faktorok indukciójának dinamikája a prekondicionált miokardiumban Cardiologia Hungarica 2002. 32; 3. 193. 2. Jancsó G, Borsiczky B, Szántó Z, Cserepes B, Gasz B, Karosi Z, Solymos A, Kiss K, Szeberényi J, Rőth E. Nukleáris Faktor-kB és A...

We examined the influence of adrenalectomy on NSAID-induced small intestinal damage in rats and investigated the possible involvement of adrenal glucocorticoids in the protective effects of urocortin I, a corticotropin-releasing factor (CRF) agonist. Male SD rats without fasting were administered indomethacin s.c. and killed 24 h later in order to examine the hemorrhagic lesions that developed ...

The corticotropin-releasing factor (CRF) system mediates stress responses. Extrahypothalamic CRF1 receptor activation has anxiogenic-like properties, but anxiety-related functions of CRF2 receptors remain unclear. The present study determined the effects of intracerebroventricular administration of a CRF2 agonist, urocortin 3, on behavior of male Wistar rats in the shock-probe, social interacti...

Peptides of the corticotropin-releasing factor (CRF) family are expressed throughout the central nervous system (CNS) and in peripheral tissues where they play diverse roles in physiology, behavior, and development. Current data supports the existence of four paralogous genes in vertebrates that encode CRF, urocortin/urotensin 1, urocortin 2 or urocortin 3. Corticotropin-releasing factor is the...

S ensitization is a ubiquitous biological phenomenon that has a role in the neuroadaptation of many different functions, from learning and memory to stress responsivity. Historically, a specific form of sensitization termed psychomotor sensitization (mistermed in my view as ‘‘behavioral sensitization’’) is induced by repeated administration of drugs of abuse and has been linked to the neuroadap...