BACKGROUND Tolvaptan (TLV) is a useful diuretic for acute decompensated heart failure (ADHF) with fluid overload, but its clinical response varies between patients. The aim of this study is to investigate whether plasma TLV concentrations correlate with the urine volume. METHODS ADHF inpatients with evidence of fluid overload and total urine volume < 1,500 mL 24 hours after initial intravenou...

The present study demonstrates a key role for the oxysterol receptor liver X receptor β (LXRβ) in the etiology of diabetes insipidus (DI). Given free access to water, LXRβ(-/-) but not LXRα(-/-) mice exhibited polyuria (abnormal daily excretion of highly diluted urine) and polydipsia (increased water intake), both features of diabetes insipidus. LXRβ(-/-) mice responded to 24-h dehydration with...

See the article "Serum and urine metabolomic biomarkers for predicting prognosis in patients with immunoglobulin A nephropathy" Volume 42 on page 591.

OBJECTIVES Histomorphologic studies have provided evidence of prostate-specific antigen (PSA)-producing tissue in the female urethra. Some urine samples from women in a small series were positive for PSA, but no systematic investigation of this subject has been done to date. METHODS In a prospective study, we analyzed whether PSA occurs in the urine of women and what factors induce detectable...

We previously reported the effectiveness of loxoprofen sodium (loxoprofen), a non-steroidal anti-inflammatory drug, for patients with lower urinary tract symptoms (LUTS) complaining of nocturia. In this study, we explored the mechanism of loxoprofen in the treatment of nocturia. Fifty-six patients complaining of nocturia were enrolled. They took a single 60-mg tablet of loxoprofen at bedtime fo...

Background & Aim: Punica granatum L. (pomegranate) is a widely used plant that has high nutritional value .This study evaluated prevention effect of hydro alcoholic extract of Punica granatum flower and leaves ethylene glycol-induced Nephrolithiasis in Wistar rats. Experimental: 20 male Wistar rats were randomly divided into 4 equal groups. G...

Background & Aim: Punica granatum L. (pomegranate) is a widely used plant that has high nutritional value .This study evaluated prevention effect of hydro alcoholic extract of Punica granatum flower and leaves ethylene glycol-induced Nephrolithiasis in Wistar rats. Experimental: 20 male Wistar rats were randomly divided into 4 equal groups. G...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background: definitions of chronic kidney disease (ckd) in many catheterization laboratories have relied on the serum creatinine (scr) rather than glomerular filtration rate (gfr). regarding that ckd is the primary predisposing factor for contrast induced nephropathy (cin), we compared the sensitivity of calculated gfr by ...

BACKGROUND The effect of flux membranes on mortality in hemodialysis (HD) patients is controversial. Residual renal function (RRF) has shown to not only be as a predictor of mortality but also a contributor to β2-microglobulin clearance in HD patients. Our study aimed to determine the interaction of residual renal function with dialyzer membrane flux on mortality in HD patients. METHODS HD Pa...