Shikimate dehydrogenase (SDH), which catalyses the NADPH-dependent reduction of 3-dehydroshikimate to shikimate in the shikimate pathway, is an attractive target for the development of herbicides and antimicrobial agents. Structural analysis of a SDH from Thermotoga maritima encoded by the Tm0346 gene was performed to facilitate further structural comparisons between the various shikimate dehyd...

REFERENCES 1 Baker, R. D.: Mucormycosis—a new disease? J.A.M.A. 163:805, 1957. 2 Hutter, R. V. P.: Phycomycetous infection (mucormycosis) in cancer patients: a complication of therapy. Cancer 12:330, 1959. 3 Gregory, J. E., Golden, A., and Haymaker, M.: Mucormycosis of the central nervous system. A report of three cases. Bull. Johns Hopkins Hosp. 73:405, 1943. * Bauer, H., Ajello, L., Adams, E....

We thank Drs Schouten and Campfens for their interest in our paper. We are more optimistic about the practical capabilities of directed coherence than the position they adopt in their letter, but we would also emphasise the need for caution in using these methods. At the basis of directed coherence (Granger causality) methods is an autoregressive model of the signals of interest. For the bivari...

The importance of polyunsaturated fatty acid (PUFA) in microalgae was widely reported. In this study, six isolated microalgae from Teluk Aling, Penang National Park were screened for PUFA contents. Isochrysis maritima showed the best polyunsaturated fatty acids essential for aquaculture species compared to other microalgal species tested. This species is a good choice as aquaculture feed due to...

Extracts from Alternanthera maritima are used in Brazilian folk medicine for the treatment of infectious and inflammatory diseases. Bioassay-guided fractionation of A. maritima aerial parts yielded an ethanolic crude extract, its butanolic fraction and seven isolated flavonoids (two aglycones, two O-glycosides and three C-glycosides) with antioxidative activity. The ability of these samples to ...